1lum

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[[Image:1lum.jpg|left|200px]]
[[Image:1lum.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1lum |SIZE=350|CAPTION= <scene name='initialview01'>1lum</scene>
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The line below this paragraph, containing "STRUCTURE_1lum", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span>
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1lum| PDB=1lum | SCENE= }}
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|RELATEDENTRY=[[1lui|1LUI]], [[1luk|1LUK]], [[1lun|1LUN]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lum OCA], [http://www.ebi.ac.uk/pdbsum/1lum PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lum RCSB]</span>
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}}
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'''NMR Structure of the Itk SH2 domain, Pro287trans, 20 low energy structures'''
'''NMR Structure of the Itk SH2 domain, Pro287trans, 20 low energy structures'''
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[[Category: Fulton, D B.]]
[[Category: Fulton, D B.]]
[[Category: Mallis, R J.]]
[[Category: Mallis, R J.]]
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[[Category: cis/trans isomerization]]
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[[Category: Cis/trans isomerization]]
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[[Category: interleukin-2 tyrosine kinase]]
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[[Category: Interleukin-2 tyrosine kinase]]
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[[Category: itk]]
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[[Category: Itk]]
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[[Category: proline]]
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[[Category: Proline]]
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[[Category: sh2]]
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[[Category: Sh2]]
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[[Category: src homology 2]]
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[[Category: Src homology 2]]
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[[Category: t-cell specific kinase]]
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[[Category: T-cell specific kinase]]
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[[Category: tsk]]
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[[Category: Tsk]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:18:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:07:38 2008''
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Revision as of 21:18, 2 May 2008

Image:1lum.jpg

Template:STRUCTURE 1lum

NMR Structure of the Itk SH2 domain, Pro287trans, 20 low energy structures


Overview

Interleukin-2 tyrosine kinase (Itk) is a T cell-specific kinase required for a proper immune response following T cell receptor engagement. In addition to the kinase domain, Itk is composed of several noncatalytic regulatory domains, including a Src homology 2 (SH2) domain that contains a conformationally heterogeneous Pro residue. Cis-trans isomerization of a single prolyl imide bond within the SH2 domain mediates conformer-specific ligand recognition that may have functional implications in T cell signaling. To better understand the mechanism by which a proline switch regulates ligand binding, we have used NMR spectroscopy to determine two structures of Itk SH2 corresponding to the cis and trans imide bond-containing conformers. The structures indicate that the heterogeneous Pro residue acts as a hinge that modulates ligand recognition by controlling the relative orientation of protein-binding surfaces.

About this Structure

1LUM is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural characterization of a proline-driven conformational switch within the Itk SH2 domain., Mallis RJ, Brazin KN, Fulton DB, Andreotti AH, Nat Struct Biol. 2002 Dec;9(12):900-5. PMID:12402030 Page seeded by OCA on Sat May 3 00:18:30 2008

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