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1luz

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[[Image:1luz.jpg|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1luz", creates the "Structure Box" on the page.
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|GENE= K3L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10245 Vaccinia virus])
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1luz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1luz OCA], [http://www.ebi.ac.uk/pdbsum/1luz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1luz RCSB]</span>
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'''Crystal Structure of the K3L Protein From Vaccinia Virus (Wisconsin Strain)'''
'''Crystal Structure of the K3L Protein From Vaccinia Virus (Wisconsin Strain)'''
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[[Category: Sicheri, F.]]
[[Category: Sicheri, F.]]
[[Category: 5 stranded anti-parallel beta barrel]]
[[Category: 5 stranded anti-parallel beta barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:19:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:07:45 2008''
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Revision as of 21:19, 2 May 2008

Image:1luz.jpg

Template:STRUCTURE 1luz

Crystal Structure of the K3L Protein From Vaccinia Virus (Wisconsin Strain)


Overview

The vaccinia virus protein K3L subverts the mammalian antiviral defense mechanism by inhibiting the RNA-dependent protein kinase PKR. K3L is a structural mimic of PKR's natural substrate, the translation initiation factor eIF2alpha. To further our understanding of K3L inhibitory function and PKR substrate recognition, we have solved the 1.8 A X-ray crystal structure of K3L. The structure consists of a five-strand beta barrel with an intervening helix insert region similar in topology to the functionally divergent S1 domain. Mutational analysis identifies two proximal regions of the K3L structure as possessing specialized PKR binding and inhibitory function. Further analysis reveals that PKR dimerization composes a key switch that regulates both its catalytic activation and its molecular recognition of K3L and eIF2alpha.

About this Structure

1LUZ is a Single protein structure of sequence from Vaccinia virus. Full crystallographic information is available from OCA.

Reference

X-ray crystal structure and functional analysis of vaccinia virus K3L reveals molecular determinants for PKR subversion and substrate recognition., Dar AC, Sicheri F, Mol Cell. 2002 Aug;10(2):295-305. PMID:12191475 Page seeded by OCA on Sat May 3 00:19:08 2008

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