1lvn

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[[Image:1lvn.gif|left|200px]]
[[Image:1lvn.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1lvn |SIZE=350|CAPTION= <scene name='initialview01'>1lvn</scene>, resolution 2.40&Aring;
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The line below this paragraph, containing "STRUCTURE_1lvn", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=TYT:TYROSINE+DERIVATIVE'>TYT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Amine_oxidase_(copper-containing) Amine oxidase (copper-containing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.6 1.4.3.6] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1lvn| PDB=1lvn | SCENE= }}
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|RELATEDENTRY=[[1oac|1OAC]], [[1spu|1SPU]], [[1d6u|1D6U]], [[1d6y|1D6Y]], [[1d6z|1D6Z]], [[1dyu|1DYU]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lvn OCA], [http://www.ebi.ac.uk/pdbsum/1lvn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lvn RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF E. COLI AMINE OXIDASE COMPLEXED WITH TRANYLCYPROMINE'''
'''CRYSTAL STRUCTURE OF E. COLI AMINE OXIDASE COMPLEXED WITH TRANYLCYPROMINE'''
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==Reference==
==Reference==
Medical implications from the crystal structure of a copper-containing amine oxidase complexed with the antidepressant drug tranylcypromine., Wilmot CM, Saysell CG, Blessington A, Conn DA, Kurtis CR, McPherson MJ, Knowles PF, Phillips SE, FEBS Lett. 2004 Oct 22;576(3):301-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15498552 15498552]
Medical implications from the crystal structure of a copper-containing amine oxidase complexed with the antidepressant drug tranylcypromine., Wilmot CM, Saysell CG, Blessington A, Conn DA, Kurtis CR, McPherson MJ, Knowles PF, Phillips SE, FEBS Lett. 2004 Oct 22;576(3):301-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15498552 15498552]
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[[Category: Amine oxidase (copper-containing)]]
 
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Phillips, S E.]]
[[Category: Phillips, S E.]]
[[Category: Wilmot, C M.]]
[[Category: Wilmot, C M.]]
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[[Category: inhibitor complex]]
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[[Category: Inhibitor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:20:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:08:02 2008''
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Revision as of 21:20, 2 May 2008

Image:1lvn.gif

Template:STRUCTURE 1lvn

CRYSTAL STRUCTURE OF E. COLI AMINE OXIDASE COMPLEXED WITH TRANYLCYPROMINE


Overview

The X-ray crystal structure of the copper-containing quinoprotein amine oxidase from E. coli has been determined in complex with the antidepressant drug tranylcypromine to 2.4 A resolution. The drug is a racemic mix of two enantiomers, but only one is seen bound to the enzyme. The other enantiomer is not acting as a substrate for the enzyme as no catalytic activity was detected when the enzyme was initially exposed to the drug. The inhibition of human copper amine oxidases could be a source of side-effects in its use as an antidepressant to inhibit the flavin-containing monoamine oxidases in the brain.

About this Structure

1LVN is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Medical implications from the crystal structure of a copper-containing amine oxidase complexed with the antidepressant drug tranylcypromine., Wilmot CM, Saysell CG, Blessington A, Conn DA, Kurtis CR, McPherson MJ, Knowles PF, Phillips SE, FEBS Lett. 2004 Oct 22;576(3):301-5. PMID:15498552 Page seeded by OCA on Sat May 3 00:20:28 2008

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