This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1lvn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1lvn.gif|left|200px]]
[[Image:1lvn.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1lvn |SIZE=350|CAPTION= <scene name='initialview01'>1lvn</scene>, resolution 2.40&Aring;
+
The line below this paragraph, containing "STRUCTURE_1lvn", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=TYT:TYROSINE+DERIVATIVE'>TYT</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Amine_oxidase_(copper-containing) Amine oxidase (copper-containing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.6 1.4.3.6] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1lvn| PDB=1lvn | SCENE= }}
-
|RELATEDENTRY=[[1oac|1OAC]], [[1spu|1SPU]], [[1d6u|1D6U]], [[1d6y|1D6Y]], [[1d6z|1D6Z]], [[1dyu|1DYU]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lvn OCA], [http://www.ebi.ac.uk/pdbsum/1lvn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lvn RCSB]</span>
+
-
}}
+
'''CRYSTAL STRUCTURE OF E. COLI AMINE OXIDASE COMPLEXED WITH TRANYLCYPROMINE'''
'''CRYSTAL STRUCTURE OF E. COLI AMINE OXIDASE COMPLEXED WITH TRANYLCYPROMINE'''
Line 23: Line 20:
==Reference==
==Reference==
Medical implications from the crystal structure of a copper-containing amine oxidase complexed with the antidepressant drug tranylcypromine., Wilmot CM, Saysell CG, Blessington A, Conn DA, Kurtis CR, McPherson MJ, Knowles PF, Phillips SE, FEBS Lett. 2004 Oct 22;576(3):301-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15498552 15498552]
Medical implications from the crystal structure of a copper-containing amine oxidase complexed with the antidepressant drug tranylcypromine., Wilmot CM, Saysell CG, Blessington A, Conn DA, Kurtis CR, McPherson MJ, Knowles PF, Phillips SE, FEBS Lett. 2004 Oct 22;576(3):301-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15498552 15498552]
-
[[Category: Amine oxidase (copper-containing)]]
 
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Phillips, S E.]]
[[Category: Phillips, S E.]]
[[Category: Wilmot, C M.]]
[[Category: Wilmot, C M.]]
-
[[Category: inhibitor complex]]
+
[[Category: Inhibitor complex]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:20:28 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:08:02 2008''
+

Revision as of 21:20, 2 May 2008

Image:1lvn.gif

Template:STRUCTURE 1lvn

CRYSTAL STRUCTURE OF E. COLI AMINE OXIDASE COMPLEXED WITH TRANYLCYPROMINE


Overview

The X-ray crystal structure of the copper-containing quinoprotein amine oxidase from E. coli has been determined in complex with the antidepressant drug tranylcypromine to 2.4 A resolution. The drug is a racemic mix of two enantiomers, but only one is seen bound to the enzyme. The other enantiomer is not acting as a substrate for the enzyme as no catalytic activity was detected when the enzyme was initially exposed to the drug. The inhibition of human copper amine oxidases could be a source of side-effects in its use as an antidepressant to inhibit the flavin-containing monoamine oxidases in the brain.

About this Structure

1LVN is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Medical implications from the crystal structure of a copper-containing amine oxidase complexed with the antidepressant drug tranylcypromine., Wilmot CM, Saysell CG, Blessington A, Conn DA, Kurtis CR, McPherson MJ, Knowles PF, Phillips SE, FEBS Lett. 2004 Oct 22;576(3):301-5. PMID:15498552 Page seeded by OCA on Sat May 3 00:20:28 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1lvn"
Personal tools