Structural highlights
Function
[CCF1_ENTFL] cCF10 is involved in the conjugative transfer of the hemolysin plasmid pCF10.
Publication Abstract from PubMed
We present the crystal structure of the pheromone receptor protein PrgZ from Enterococcus faecalis in complex with the heptapeptide cCF10 (LVTLVFV), which is used in signaling between conjugative recipient and donor cells. Comparison of PrgZ with homologous oligopeptide-binding proteins (AppA and OppA) explains the high specificity of PrgZ for hydrophobic heptapeptides versus the promiscuity of peptide binding in the homologous proteins.
Structure and Mode of Peptide Binding of Pheromone Receptor PrgZ.,Berntsson RP, Schuurman-Wolters GK, Dunny G, Slotboom DJ, Poolman B J Biol Chem. 2012 Oct 26;287(44):37165-70. doi: 10.1074/jbc.M112.386334. Epub, 2012 Sep 4. PMID:22948145[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Berntsson RP, Schuurman-Wolters GK, Dunny G, Slotboom DJ, Poolman B. Structure and Mode of Peptide Binding of Pheromone Receptor PrgZ. J Biol Chem. 2012 Oct 26;287(44):37165-70. doi: 10.1074/jbc.M112.386334. Epub, 2012 Sep 4. PMID:22948145 doi:http://dx.doi.org/10.1074/jbc.M112.386334
