4iut
From Proteopedia
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==crystal structure of SHH1 SAWADEE domain in complex with H3K9me2 peptide== | ==crystal structure of SHH1 SAWADEE domain in complex with H3K9me2 peptide== | ||
- | <StructureSection load='4iut' size='340' side='right' caption='[[4iut]], [[Resolution|resolution]] 2.70Å' scene=''> | + | <StructureSection load='4iut' size='340' side='right'caption='[[4iut]], [[Resolution|resolution]] 2.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[4iut]] is a 3 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4iut]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IUT FirstGlance]. <br> |
- | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CVM:CYMAL-4'>CVM</scene>, | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CVM:CYMAL-4'>CVM</scene>, <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
- | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iut OCA], [https://pdbe.org/4iut PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iut RCSB], [https://www.ebi.ac.uk/pdbsum/4iut PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iut ProSAT]</span></td></tr> | |
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- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
+ | == Function == | ||
+ | [https://www.uniprot.org/uniprot/SHH1_ARATH SHH1_ARATH] Involved in RNA-directed DNA methylation (RdDM). Required for the silencing of some endogenous RdDM targets and accumulation of 24-nt siRNAs, but not for the production of Pol V-dependent transcripts. Functions in transcriptional silencing through both DNA methylation-dependent and -independent pathways. Required for both maintenance and de-novo DNA methylation. Plays a role in the recruitment of Pol IV to genomic regions associated with K9 methylated histone H3 that are targets for RdDM.<ref>PMID:21811420</ref> <ref>PMID:22064704</ref> <ref>PMID:23636332</ref> <ref>PMID:23637343</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
- | [[Category: | + | [[Category: Arabidopsis thaliana]] |
- | [[Category: | + | [[Category: Large Structures]] |
- | [[Category: | + | [[Category: Du J]] |
- | [[Category: | + | [[Category: Patel DJ]] |
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Revision as of 21:13, 16 November 2022
crystal structure of SHH1 SAWADEE domain in complex with H3K9me2 peptide
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