1lww

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1lww.gif|left|200px]]
[[Image:1lww.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1lww |SIZE=350|CAPTION= <scene name='initialview01'>1lww</scene>, resolution 2.1&Aring;
+
The line below this paragraph, containing "STRUCTURE_1lww", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=BRG:8-BROMOGUANINE'>BRG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=PED:PENTANE-3,4-DIOL-5-PHOSPHATE'>PED</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= ogg1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1lww| PDB=1lww | SCENE= }}
-
|RELATEDENTRY=[[1hu0|1HU0]], [[1lwv|1LWV]], [[1lwy|1LWY]], [[1ebm|1EBM]], [[1fn7|1FN7]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lww OCA], [http://www.ebi.ac.uk/pdbsum/1lww PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lww RCSB]</span>
+
-
}}
+
'''Borohydride-trapped hOgg1 Intermediate Structure Co-Crystallized with 8-bromoguanine'''
'''Borohydride-trapped hOgg1 Intermediate Structure Co-Crystallized with 8-bromoguanine'''
Line 30: Line 27:
[[Category: Verdine, G L.]]
[[Category: Verdine, G L.]]
[[Category: Yang, W.]]
[[Category: Yang, W.]]
-
[[Category: borohydride]]
+
[[Category: Borohydride]]
-
[[Category: covalent trapping]]
+
[[Category: Covalent trapping]]
-
[[Category: dna glycosylase]]
+
[[Category: Dna glycosylase]]
-
[[Category: dna repair]]
+
[[Category: Dna repair]]
-
[[Category: product-assisted catalysis]]
+
[[Category: Product-assisted catalysis]]
-
[[Category: protein/dna]]
+
[[Category: Protein/dna]]
-
[[Category: reaction intermediate]]
+
[[Category: Reaction intermediate]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:23:01 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:08:29 2008''
+

Revision as of 21:23, 2 May 2008

Image:1lww.gif

Template:STRUCTURE 1lww

Borohydride-trapped hOgg1 Intermediate Structure Co-Crystallized with 8-bromoguanine


Overview

Most spontaneous damage to bases in DNA is corrected through the action of the base-excision DNA repair pathway. Base excision repair is initiated by DNA glycosylases, lesion-specific enzymes that intercept aberrant bases in DNA and catalyze their excision. How such proteins accomplish the feat of catalyzing no fewer than five sequential reaction steps using a single active site has been unknown. To help answer this, we report the structure of a trapped catalytic intermediate in DNA repair by human 8-oxoguanine DNA glycosylase. This structure and supporting biochemical results reveal that the enzyme sequesters the excised lesion base and exploits it as a cofactor to participate in catalysis. To our knowledge, the present example represents the first documented case of product-assisted catalysis in an enzyme-catalyzed reaction.

About this Structure

1LWW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Product-assisted catalysis in base-excision DNA repair., Fromme JC, Bruner SD, Yang W, Karplus M, Verdine GL, Nat Struct Biol. 2003 Mar;10(3):204-11. PMID:12592398 Page seeded by OCA on Sat May 3 00:23:01 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1lww"
Personal tools