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3nfz

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==Crystal structure of murine aminoacylase 3 in complex with N-acetyl-L-tyrosine==
==Crystal structure of murine aminoacylase 3 in complex with N-acetyl-L-tyrosine==
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<StructureSection load='3nfz' size='340' side='right' caption='[[3nfz]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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<StructureSection load='3nfz' size='340' side='right'caption='[[3nfz]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3nfz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NFZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NFZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3nfz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NFZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NFZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3NF:N-ACETYL-L-TYROSINE'>3NF</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3NF:N-ACETYL-L-TYROSINE'>3NF</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3nh4|3nh4]], [[3nh5|3nh5]], [[3nh8|3nh8]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3nh4|3nh4]], [[3nh5|3nh5]], [[3nh8|3nh8]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ACY-3, Acy3, Aspa2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ACY-3, Acy3, Aspa2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nfz OCA], [http://pdbe.org/3nfz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3nfz RCSB], [http://www.ebi.ac.uk/pdbsum/3nfz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3nfz ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nfz OCA], [https://pdbe.org/3nfz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nfz RCSB], [https://www.ebi.ac.uk/pdbsum/3nfz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nfz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ACY3_MOUSE ACY3_MOUSE]] Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acids.<ref>PMID:14656720</ref> <ref>PMID:17012540</ref>
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[[https://www.uniprot.org/uniprot/ACY3_MOUSE ACY3_MOUSE]] Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acids.<ref>PMID:14656720</ref> <ref>PMID:17012540</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Aspartoacylase|Aspartoacylase]]
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*[[Aminoacylase 3D structures|Aminoacylase 3D structures]]
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*[[Aspartoacylase 3D structures|Aspartoacylase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Lk3 transgenic mice]]
[[Category: Abramson, J]]
[[Category: Abramson, J]]

Revision as of 07:01, 12 May 2022

Crystal structure of murine aminoacylase 3 in complex with N-acetyl-L-tyrosine

PDB ID 3nfz

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