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| | ==Structure of PAV1-137, a protein from the virus PAV1 that infects Pyrococcus abyssi.== | | ==Structure of PAV1-137, a protein from the virus PAV1 that infects Pyrococcus abyssi.== |
| - | <StructureSection load='4hr1' size='340' side='right' caption='[[4hr1]], [[Resolution|resolution]] 2.50Å' scene=''> | + | <StructureSection load='4hr1' size='340' side='right'caption='[[4hr1]], [[Resolution|resolution]] 2.50Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4hr1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_abyssi_virus_1 Pyrococcus abyssi virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HR1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HR1 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4hr1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_abyssi_virus_1 Pyrococcus abyssi virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HR1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HR1 FirstGlance]. <br> |
| - | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ORF137, Pav1-137 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=425386 Pyrococcus abyssi virus 1]), ORF137 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=425386 Pyrococcus abyssi virus 1])</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hr1 OCA], [https://pdbe.org/4hr1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hr1 RCSB], [https://www.ebi.ac.uk/pdbsum/4hr1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hr1 ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hr1 OCA], [http://pdbe.org/4hr1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hr1 RCSB], [http://www.ebi.ac.uk/pdbsum/4hr1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hr1 ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/A5Y2E1_9VIRU A5Y2E1_9VIRU] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| | + | [[Category: Large Structures]] |
| | [[Category: Pyrococcus abyssi virus 1]] | | [[Category: Pyrococcus abyssi virus 1]] |
| - | [[Category: Flament, D]] | + | [[Category: Flament D]] |
| - | [[Category: Geslin, C]] | + | [[Category: Geslin C]] |
| - | [[Category: Graille, M]] | + | [[Category: Graille M]] |
| - | [[Category: Leulliot, N]] | + | [[Category: Leulliot N]] |
| - | [[Category: Quevillon-Cheruel, S]] | + | [[Category: Quevillon-Cheruel S]] |
| - | [[Category: Romancer, M L]] | + | [[Category: Romancer ML]] |
| - | [[Category: Tilbeurgh, H V]] | + | [[Category: Tilbeurgh HV]] |
| - | [[Category: Helical bundle]]
| + | |
| - | [[Category: Unknown function]]
| + | |
| Structural highlights
Function
A5Y2E1_9VIRU
Publication Abstract from PubMed
Pyrococcus abyssi virus 1 (PAV1) was the first virus particle infecting a hyperthermophilic Euryarchaeota (Pyrococcus abyssi strain GE23) that has been isolated and characterized. It is lemon shaped and is decorated with a short fibered tail. PAV1 morphologically resembles the fusiform members of the family Fuselloviridae or the genus Salterprovirus. The 18 kb dsDNA genome of PAV1 contains 25 predicted genes, most of them of unknown function. To help assigning functions to these proteins, we have initiated structural studies of the PAV1 proteome. We determined the crystal structure of a putative protein of 137 residues (PAV1-137) at a resolution of 2.2 A. The protein forms dimers both in solution and in the crystal. The fold of PAV1-137 is a four- alpha -helical bundle analogous to those found in some eukaryotic adhesion proteins such as focal adhesion kinase, suggesting that PAV1-137 is involved in protein-protein interactions.
Crystal structure of PAV1-137: a protein from the virus PAV1 that infects Pyrococcus abyssi.,Leulliot N, Quevillon-Cheruel S, Graille M, Geslin C, Flament D, Le Romancer M, van Tilbeurgh H Archaea. 2013;2013:568053. doi: 10.1155/2013/568053. Epub 2013 Mar 4. PMID:23533329[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Leulliot N, Quevillon-Cheruel S, Graille M, Geslin C, Flament D, Le Romancer M, van Tilbeurgh H. Crystal structure of PAV1-137: a protein from the virus PAV1 that infects Pyrococcus abyssi. Archaea. 2013;2013:568053. doi: 10.1155/2013/568053. Epub 2013 Mar 4. PMID:23533329 doi:10.1155/2013/568053
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