4mq4
From Proteopedia
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<StructureSection load='4mq4' size='340' side='right' caption='[[4mq4]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='4mq4' size='340' side='right' caption='[[4mq4]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4mq4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MQ4 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4mq4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MQ4 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2D5:5-S-(3-{[(3R)-1,2,3,4-TETRAHYDROISOQUINOLIN-3-YLCARBONYL]AMINO}PROPYL)-5-THIOADENOSINE'>2D5</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2D5:5-S-(3-{[(3R)-1,2,3,4-TETRAHYDROISOQUINOLIN-3-YLCARBONYL]AMINO}PROPYL)-5-THIOADENOSINE'>2D5</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1hnn|1hnn]], [[2g72|2g72]], [[4mik|4mik]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1hnn|1hnn]], [[2g72|2g72]], [[4mik|4mik]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PNMT, PENT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylethanolamine_N-methyltransferase Phenylethanolamine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.28 2.1.1.28] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylethanolamine_N-methyltransferase Phenylethanolamine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.28 2.1.1.28] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mq4 OCA], [http://pdbe.org/4mq4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mq4 RCSB], [http://www.ebi.ac.uk/pdbsum/4mq4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mq4 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mq4 OCA], [http://pdbe.org/4mq4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mq4 RCSB], [http://www.ebi.ac.uk/pdbsum/4mq4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mq4 ProSAT]</span></td></tr> | ||
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/PNMT_HUMAN PNMT_HUMAN]] Converts noradrenaline to adrenaline. | [[http://www.uniprot.org/uniprot/PNMT_HUMAN PNMT_HUMAN]] Converts noradrenaline to adrenaline. | ||
| - | |||
| - | ==See Also== | ||
| - | *[[Phenylethanolamine N-methyltransferase|Phenylethanolamine N-methyltransferase]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Phenylethanolamine N-methyltransferase]] | [[Category: Phenylethanolamine N-methyltransferase]] | ||
[[Category: Bart, A G]] | [[Category: Bart, A G]] | ||
Revision as of 20:11, 24 January 2018
Crystal Structure of hPNMT in Complex with bisubstrate inhibitor N-(3-((((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)thio)propyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
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