1m1c
From Proteopedia
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'''Structure of the L-A virus''' | '''Structure of the L-A virus''' | ||
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[[Category: Tang, J.]] | [[Category: Tang, J.]] | ||
[[Category: Wickner, R B.]] | [[Category: Wickner, R B.]] | ||
| - | [[Category: | + | [[Category: Dsrna virus structure]] |
| - | [[Category: | + | [[Category: Icosahedral virus]] |
| - | [[Category: | + | [[Category: L-a virus]] |
| - | [[Category: | + | [[Category: Mrna decapping]] |
| - | [[Category: | + | [[Category: Quai-equivalence]] |
| - | [[Category: | + | [[Category: Rna-protein interaction]] |
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Revision as of 21:30, 2 May 2008
Structure of the L-A virus
Overview
The structure of the yeast L-A virus was determined by X-ray crystallography at 3.4 A resolution. The L-A dsRNA virus is 400 A in diameter and contains a single protein shell of 60 asymmetric dimers of the coat protein, a feature common among the inner protein shells of dsRNA viruses and probably related to their unique mode of transcription and replication. The two identical subunits in each dimer are in non-equivalent environments and show substantially different conformations in specific surface regions. The L-A virus decaps cellular mRNA to efficiently translate its own uncapped mRNA. Our structure reveals a trench at the active site of the decapping reaction and suggests a role for nearby residues in the reaction.
About this Structure
1M1C is a Single protein structure of sequence from Viruses. Full crystallographic information is available from OCA.
Reference
L-A virus at 3.4 A resolution reveals particle architecture and mRNA decapping mechanism., Naitow H, Tang J, Canady M, Wickner RB, Johnson JE, Nat Struct Biol. 2002 Oct;9(10):725-8. PMID:12244300 Page seeded by OCA on Sat May 3 00:30:44 2008
