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3ik5

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==SIVmac239 Nef in complex with TCR zeta ITAM 1 polypeptide (A63-R80)==
==SIVmac239 Nef in complex with TCR zeta ITAM 1 polypeptide (A63-R80)==
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<StructureSection load='3ik5' size='340' side='right' caption='[[3ik5]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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<StructureSection load='3ik5' size='340' side='right'caption='[[3ik5]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ik5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Siv_-_cpz Siv - cpz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IK5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IK5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ik5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Siv_-_cpz Siv - cpz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IK5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IK5 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">nef ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=388909 SIV - cpz])</td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">nef ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=388909 SIV - cpz])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ik5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ik5 OCA], [http://pdbe.org/3ik5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ik5 RCSB], [http://www.ebi.ac.uk/pdbsum/3ik5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ik5 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ik5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ik5 OCA], [https://pdbe.org/3ik5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ik5 RCSB], [https://www.ebi.ac.uk/pdbsum/3ik5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ik5 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/CD3Z_HUMAN CD3Z_HUMAN]] Defects in CD247 are the cause of immunodeficiency due to defect in CD3-zeta (CD3ZID) [MIM:[http://omim.org/entry/610163 610163]]. An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens.<ref>PMID:16672702</ref>
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[[https://www.uniprot.org/uniprot/CD3Z_HUMAN CD3Z_HUMAN]] Defects in CD247 are the cause of immunodeficiency due to defect in CD3-zeta (CD3ZID) [MIM:[https://omim.org/entry/610163 610163]]. An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens.<ref>PMID:16672702</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CD3Z_HUMAN CD3Z_HUMAN]] Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.
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[[https://www.uniprot.org/uniprot/CD3Z_HUMAN CD3Z_HUMAN]] Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ik/3ik5_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ik/3ik5_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[CD3|CD3]]
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*[[CD3 3D structures|CD3 3D structures]]
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*[[Protein Nef|Protein Nef]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Siv - cpz]]
[[Category: Siv - cpz]]
[[Category: Kim, W M]]
[[Category: Kim, W M]]

Revision as of 03:34, 21 April 2022

SIVmac239 Nef in complex with TCR zeta ITAM 1 polypeptide (A63-R80)

PDB ID 3ik5

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