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4fmw

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Current revision (19:59, 19 October 2022) (edit) (undo)
 
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==Crystal structure of methyltransferase domain of human RNA (guanine-9-) methyltransferase domain containing protein 2==
==Crystal structure of methyltransferase domain of human RNA (guanine-9-) methyltransferase domain containing protein 2==
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<StructureSection load='4fmw' size='340' side='right' caption='[[4fmw]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='4fmw' size='340' side='right'caption='[[4fmw]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4fmw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FMW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FMW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4fmw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FMW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FMW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fmw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fmw OCA], [https://pdbe.org/4fmw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fmw RCSB], [https://www.ebi.ac.uk/pdbsum/4fmw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fmw ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RG9MTD2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fmw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fmw OCA], [http://pdbe.org/4fmw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fmw RCSB], [http://www.ebi.ac.uk/pdbsum/4fmw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fmw ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/TM10A_HUMAN TM10A_HUMAN]] Primary microcephaly-mild intellectual disability-young-onset diabetes syndrome. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/TM10A_HUMAN TM10A_HUMAN] Primary microcephaly-mild intellectual disability-young-onset diabetes syndrome. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TM10A_HUMAN TM10A_HUMAN]] RNA methyltransferase.<ref>PMID:25053765</ref>
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[https://www.uniprot.org/uniprot/TM10A_HUMAN TM10A_HUMAN] RNA methyltransferase.<ref>PMID:25053765</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H]]
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[[Category: Large Structures]]
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[[Category: Bountra, C]]
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[[Category: Arrowsmith CH]]
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[[Category: Dong, A]]
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[[Category: Bountra C]]
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[[Category: Edwards, A M]]
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[[Category: Dong A]]
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[[Category: Loppnau, P]]
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[[Category: Edwards AM]]
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[[Category: Structural genomic]]
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[[Category: Loppnau P]]
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[[Category: Tempel, W]]
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[[Category: Tempel W]]
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[[Category: Weigelt, J]]
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[[Category: Weigelt J]]
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[[Category: Wu, H]]
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[[Category: Wu H]]
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[[Category: Zeng, H]]
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[[Category: Zeng H]]
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[[Category: Guanine]]
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[[Category: Rna methylation]]
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[[Category: Rna methyltransferase]]
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[[Category: Rna modification]]
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[[Category: Sgc]]
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[[Category: Transferase]]
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Current revision

Crystal structure of methyltransferase domain of human RNA (guanine-9-) methyltransferase domain containing protein 2

PDB ID 4fmw

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