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| | ==Crystal structure of zebrafish MO25== | | ==Crystal structure of zebrafish MO25== |
| - | <StructureSection load='4kzg' size='340' side='right' caption='[[4kzg]], [[Resolution|resolution]] 2.90Å' scene=''> | + | <StructureSection load='4kzg' size='340' side='right'caption='[[4kzg]], [[Resolution|resolution]] 2.90Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4kzg]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KZG FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4kzg]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KZG FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cab39 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kzg OCA], [https://pdbe.org/4kzg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kzg RCSB], [https://www.ebi.ac.uk/pdbsum/4kzg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kzg ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kzg OCA], [http://pdbe.org/4kzg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kzg RCSB], [http://www.ebi.ac.uk/pdbsum/4kzg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kzg ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/Q6IQL2_DANRE Q6IQL2_DANRE] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Brachidanio rerio]] | + | [[Category: Danio rerio]] |
| - | [[Category: Shi, Z B]] | + | [[Category: Large Structures]] |
| - | [[Category: Zhang, M]] | + | [[Category: Shi ZB]] |
| - | [[Category: Zhang, Z Z]] | + | [[Category: Zhang M]] |
| - | [[Category: Kinase activator]] | + | [[Category: Zhang ZZ]] |
| - | [[Category: Scaffold protein]]
| + | |
| - | [[Category: Signaling protein]]
| + | |
| - | [[Category: Ste20 kinase]]
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| Structural highlights
Function
Q6IQL2_DANRE
Publication Abstract from PubMed
MO25, a conserved scaffold protein, activates the tumour suppressor LKB1 with the pseudokinase STRAD. MO25 also promotes the activities of the STE20-family kinases MST3, MST4, STK25, SPAK and OSR1. Zebrafish MO25 was purified and crystallized, and a crystal of zebrafish MO25 diffracted to 2.9 A resolution and belonged to space group P3221, with unit-cell parameters a = b = 156.665, c = 221.251 A. The structure of zebrafish MO25 was determined by molecular replacement. It is constituted of seven helical repeats. Structural comparison indicates that the overall structures of zebrafish and human MO25 are very similar, suggesting that MO25 has conserved functions in zebrafish. This work provides a structural basis for further functional and evolutionary studies of MO25.
Structure of zebrafish MO25.,Zhang Z, Wang Y, Shi Z, Zhang M Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Sep;69(Pt 9):989-93. doi: , 10.1107/S1744309113021520. Epub 2013 Aug 23. PMID:23989145[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Zhang Z, Wang Y, Shi Z, Zhang M. Structure of zebrafish MO25. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Sep;69(Pt 9):989-93. doi: , 10.1107/S1744309113021520. Epub 2013 Aug 23. PMID:23989145 doi:10.1107/S1744309113021520
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