1m4r

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[[Image:1m4r.jpg|left|200px]]
[[Image:1m4r.jpg|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1m4r", creates the "Structure Box" on the page.
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{{STRUCTURE_1m4r| PDB=1m4r | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4r OCA], [http://www.ebi.ac.uk/pdbsum/1m4r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1m4r RCSB]</span>
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'''CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-22'''
'''CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-22'''
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[[Category: Polikarpov, I.]]
[[Category: Polikarpov, I.]]
[[Category: Renauld, J C.]]
[[Category: Renauld, J C.]]
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[[Category: crystal structure]]
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[[Category: Crystal structure]]
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[[Category: cytokine]]
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[[Category: Cytokine]]
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[[Category: interferon-gamma]]
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[[Category: Interferon-gamma]]
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[[Category: interleukin-10 (il-10)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:37:41 2008''
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[[Category: interleukin-22 (il-22)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:11:14 2008''
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Revision as of 21:37, 2 May 2008

Image:1m4r.jpg

Template:STRUCTURE 1m4r

CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-22


Overview

Interleukin-22 (IL-10-related T cell-derived inducible factor/IL-TIF/IL-22) is a novel cytokine belonging to the IL-10 family. Recombinant human IL-22 (hIL-22) was found to activate the signal transducers and activators of transcription factors 1 and 3 as well as acute phase reactants in several hepatoma cell lines, suggesting its involvement in the inflammatory response. The crystallographic structure of recombinant hIL-22 has been solved at 2.0 A resolution using the SIRAS method. Contrary to IL-10, the hIL-22 dimer does not present an interpenetration of the secondary-structure elements belonging to the two distinct polypeptide chains but results from interface interactions between monomers. Structural differences between these two cytokines, revealed by the crystallographic studies, clearly indicate that, while a homodimer of IL-10 is required for signaling, hIL-22 most probably interacts with its receptor as a monomer.

About this Structure

1M4R is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of recombinant human interleukin-22., Nagem RA, Colau D, Dumoutier L, Renauld JC, Ogata C, Polikarpov I, Structure. 2002 Aug;10(8):1051-62. PMID:12176383 Page seeded by OCA on Sat May 3 00:37:41 2008

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