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3qve
From Proteopedia
(Difference between revisions)
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==Crystal structure of human HMG box-containing protein 1, HBP1== | ==Crystal structure of human HMG box-containing protein 1, HBP1== | ||
| - | <StructureSection load='3qve' size='340' side='right' caption='[[3qve]], [[Resolution|resolution]] 2.04Å' scene=''> | + | <StructureSection load='3qve' size='340' side='right'caption='[[3qve]], [[Resolution|resolution]] 2.04Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3qve]] is a 3 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3qve]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QVE FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HBP1 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HBP1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qve OCA], [https://pdbe.org/3qve PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qve RCSB], [https://www.ebi.ac.uk/pdbsum/3qve PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qve ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/HBP1_HUMAN HBP1_HUMAN]] Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.<ref>PMID:10958660</ref> <ref>PMID:10562551</ref> <ref>PMID:11500377</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Arrowsmith, C H]] | [[Category: Arrowsmith, C H]] | ||
[[Category: Bountra, C]] | [[Category: Bountra, C]] | ||
Revision as of 05:37, 15 June 2022
Crystal structure of human HMG box-containing protein 1, HBP1
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Categories: Human | Large Structures | Arrowsmith, C H | Bountra, C | Chaikuad, A | Cocking, R | Structural genomic | Delft, F von | Edwards, A M | Filippakopoulos, P | Krojer, T | Krysztofinska, E | Oppermann, U | Ugochukwu, E | Vollmar, M | Weigelt, J | Yue, W W | Axh domain | Hbp1 | Hmg box transcription factor 1 | Sgc | Transcription
