1m6r

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[[Image:1m6r.gif|left|200px]]
[[Image:1m6r.gif|left|200px]]
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{{Structure
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|PDB= 1m6r |SIZE=350|CAPTION= <scene name='initialview01'>1m6r</scene>, resolution 1.54&Aring;
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The line below this paragraph, containing "STRUCTURE_1m6r", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>
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{{STRUCTURE_1m6r| PDB=1m6r | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m6r OCA], [http://www.ebi.ac.uk/pdbsum/1m6r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1m6r RCSB]</span>
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'''Crystal structure of rGd(CGCGCG) forming hexamer Z-DNA duplex with 5'-(rG) overhang'''
'''Crystal structure of rGd(CGCGCG) forming hexamer Z-DNA duplex with 5'-(rG) overhang'''
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==About this Structure==
==About this Structure==
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1M6R is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M6R OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M6R OCA].
==Reference==
==Reference==
Crystal structure of rGd(CGCGCG): a Z-DNA hexamer duplex with a 5'-(rG) overhang., Pan B, Sundaralingam M, Acta Crystallogr D Biol Crystallogr. 2003 Mar;59(Pt 3):433-7. Epub 2003, Feb 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12595699 12595699]
Crystal structure of rGd(CGCGCG): a Z-DNA hexamer duplex with a 5'-(rG) overhang., Pan B, Sundaralingam M, Acta Crystallogr D Biol Crystallogr. 2003 Mar;59(Pt 3):433-7. Epub 2003, Feb 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12595699 12595699]
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[[Category: Protein complex]]
 
[[Category: Pan, B.]]
[[Category: Pan, B.]]
[[Category: Sundaralingam, M.]]
[[Category: Sundaralingam, M.]]
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[[Category: overhang]]
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[[Category: Overhang]]
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[[Category: z-dna]]
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[[Category: Z-dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:42:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:12:07 2008''
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Revision as of 21:42, 2 May 2008

Image:1m6r.gif

Template:STRUCTURE 1m6r

Crystal structure of rGd(CGCGCG) forming hexamer Z-DNA duplex with 5'-(rG) overhang


Overview

The crystal structure of the heptamer rGd(CGCGCG) has been determined at 1.54 A resolution with R(work) and R(free) of 0.191 and 0.235, respectively. The crystal belongs to space group P2(1)2(1)2(1), with unit-cell parameters a = 17.96, b = 31.47, c = 44.73 A and two independent strands in the asymmetric unit. The chimera forms a Z-DNA hexamer duplex d(CGCGCG)(2), with the 5'-overhang rG invisible in the density. The replacement of rG in the 5' terminus of d(GCGCGCG) changes the reverse Hoogsteen G.G base pairing of the 5'-overhang dG (Pan et al., 1997). However, the replacement does not change the helix from Z-form to A-form or the water-structure motifs in the Z-DNA double-helical structure.

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of rGd(CGCGCG): a Z-DNA hexamer duplex with a 5'-(rG) overhang., Pan B, Sundaralingam M, Acta Crystallogr D Biol Crystallogr. 2003 Mar;59(Pt 3):433-7. Epub 2003, Feb 21. PMID:12595699 Page seeded by OCA on Sat May 3 00:42:10 2008

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