This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4dw6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
==Novel N-phenyl-phenoxyacetamide derivatives as potential EthR inhibitors and ethionamide boosters. Discovery and optimization using High-Throughput Synthesis.==
==Novel N-phenyl-phenoxyacetamide derivatives as potential EthR inhibitors and ethionamide boosters. Discovery and optimization using High-Throughput Synthesis.==
-
<StructureSection load='4dw6' size='340' side='right' caption='[[4dw6]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+
<StructureSection load='4dw6' size='340' side='right'caption='[[4dw6]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4dw6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DW6 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4dw6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DW6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DW6 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0MN:N-[4-(1,3-BENZOTHIAZOL-2-YL)PHENYL]-2-(3-METHOXYPHENOXY)ACETAMIDE'>0MN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0MN:N-[4-(1,3-BENZOTHIAZOL-2-YL)PHENYL]-2-(3-METHOXYPHENOXY)ACETAMIDE'>0MN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">etaR, ethR, MT3970, Rv3855 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dw6 OCA], [https://pdbe.org/4dw6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dw6 RCSB], [https://www.ebi.ac.uk/pdbsum/4dw6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dw6 ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dw6 OCA], [http://pdbe.org/4dw6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4dw6 RCSB], [http://www.ebi.ac.uk/pdbsum/4dw6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4dw6 ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU]] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref>
+
[[https://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU]] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 19: Line 18:
</div>
</div>
<div class="pdbe-citations 4dw6" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4dw6" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Baulard, A R]]
+
[[Category: Large Structures]]
-
[[Category: Brodin, P]]
+
[[Category: Mycobacterium tuberculosis]]
-
[[Category: Christophe, T]]
+
[[Category: Baulard AR]]
-
[[Category: Deprez, B]]
+
[[Category: Brodin P]]
-
[[Category: Desroses, M]]
+
[[Category: Christophe T]]
-
[[Category: Flipo, M]]
+
[[Category: Deprez B]]
-
[[Category: Hounsou, C]]
+
[[Category: Desroses M]]
-
[[Category: Jeon, H K]]
+
[[Category: Flipo M]]
-
[[Category: Lecat-Guillet, N]]
+
[[Category: Hounsou C]]
-
[[Category: Lens, Z]]
+
[[Category: Jeon HK]]
-
[[Category: Leroux, F]]
+
[[Category: Lecat-Guillet N]]
-
[[Category: Locht, C]]
+
[[Category: Lens Z]]
-
[[Category: Villeret, V]]
+
[[Category: Leroux F]]
-
[[Category: Willand, N]]
+
[[Category: Locht C]]
-
[[Category: Wintjens, R]]
+
[[Category: Villeret V]]
-
[[Category: Wohlkonig, A]]
+
[[Category: Willand N]]
-
[[Category: Dna binding protein]]
+
[[Category: Wintjens R]]
-
[[Category: Inhibitor]]
+
[[Category: Wohlkonig A]]
-
[[Category: Tetr-family]]
+
-
[[Category: Transcription repressor-inhibitor complex]]
+
-
[[Category: Transcription-inhibitor complex]]
+
-
[[Category: Transcritptional regulatory repressor]]
+

Revision as of 08:41, 21 September 2022

Novel N-phenyl-phenoxyacetamide derivatives as potential EthR inhibitors and ethionamide boosters. Discovery and optimization using High-Throughput Synthesis.

PDB ID 4dw6

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4dw6"
Personal tools