1maa

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[[Image:1maa.gif|left|200px]]
[[Image:1maa.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1maa |SIZE=350|CAPTION= <scene name='initialview01'>1maa</scene>, resolution 2.9&Aring;
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The line below this paragraph, containing "STRUCTURE_1maa", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DME:DECAMETHONIUM+ION'>DME</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= MOUSE ACHE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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-->
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|DOMAIN=
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{{STRUCTURE_1maa| PDB=1maa | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1maa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1maa OCA], [http://www.ebi.ac.uk/pdbsum/1maa PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1maa RCSB]</span>
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}}
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'''MOUSE ACETYLCHOLINESTERASE CATALYTIC DOMAIN, GLYCOSYLATED PROTEIN'''
'''MOUSE ACETYLCHOLINESTERASE CATALYTIC DOMAIN, GLYCOSYLATED PROTEIN'''
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[[Category: Marchot, P.]]
[[Category: Marchot, P.]]
[[Category: Taylor, P.]]
[[Category: Taylor, P.]]
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[[Category: acetylcholinesterase]]
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[[Category: Acetylcholinesterase]]
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[[Category: glycosylated protein]]
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[[Category: Glycosylated protein]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: hydrolase fold]]
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[[Category: Hydrolase fold]]
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[[Category: serine esterase]]
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[[Category: Serine esterase]]
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[[Category: tetramer]]
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[[Category: Tetramer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:49:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:13:29 2008''
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Revision as of 21:49, 2 May 2008

Image:1maa.gif

Template:STRUCTURE 1maa

MOUSE ACETYLCHOLINESTERASE CATALYTIC DOMAIN, GLYCOSYLATED PROTEIN


Overview

The crystal structure of mouse acetylcholinesterase at 2.9-A resolution reveals a tetrameric assembly of subunits with an antiparallel alignment of two canonical homodimers assembled through four-helix bundles. In the tetramer, a short Omega loop, composed of a cluster of hydrophobic residues conserved in mammalian acetylcholinesterases along with flanking alpha-helices, associates with the peripheral anionic site of the facing subunit and sterically occludes the entrance of the gorge leading to the active center. The inverse loop-peripheral site interaction occurs within the second pair of subunits, but the peripheral sites on the two loop-donor subunits remain freely accessible to the solvent. The position and complementarity of the peripheral site-occluding loop mimic the characteristics of the central loop of the peptidic inhibitor fasciculin bound to mouse acetylcholinesterase. Tetrameric forms of cholinesterases are widely distributed in nature and predominate in mammalian brain. This structure reveals a likely mode of subunit arrangement and suggests that the peripheral site, located near the rim of the gorge, is a site for association of neighboring subunits or heterologous proteins with interactive surface loops.

About this Structure

1MAA is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of mouse acetylcholinesterase. A peripheral site-occluding loop in a tetrameric assembly., Bourne Y, Taylor P, Bougis PE, Marchot P, J Biol Chem. 1999 Jan 29;274(5):2963-70. PMID:9915834 Page seeded by OCA on Sat May 3 00:49:11 2008

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