4ee0

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==Crystal structure of hH-PGDS with water displacing inhibitor==
==Crystal structure of hH-PGDS with water displacing inhibitor==
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<StructureSection load='4ee0' size='340' side='right' caption='[[4ee0]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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<StructureSection load='4ee0' size='340' side='right'caption='[[4ee0]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ee0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EE0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EE0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ee0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EE0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EE0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0O4:4-(ISOQUINOLIN-1-YL)-N-[2-(MORPHOLIN-4-YL)ETHYL]BENZAMIDE'>0O4</scene>, <scene name='pdbligand=GSF:L-GAMMA-GLUTAMYL-3-SULFINO-L-ALANYLGLYCINE'>GSF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0O4:4-(ISOQUINOLIN-1-YL)-N-[2-(MORPHOLIN-4-YL)ETHYL]BENZAMIDE'>0O4</scene>, <scene name='pdbligand=GSF:L-GAMMA-GLUTAMYL-3-SULFINO-L-ALANYLGLYCINE'>GSF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4edz|4edz]], [[4edy|4edy]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ee0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ee0 OCA], [https://pdbe.org/4ee0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ee0 RCSB], [https://www.ebi.ac.uk/pdbsum/4ee0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ee0 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GSTS, HPGDS, PGDS, PTGDS2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ee0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ee0 OCA], [http://pdbe.org/4ee0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ee0 RCSB], [http://www.ebi.ac.uk/pdbsum/4ee0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ee0 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HPGDS_HUMAN HPGDS_HUMAN]] Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.<ref>PMID:10824118</ref> <ref>PMID:11672424</ref> <ref>PMID:9425264</ref> <ref>PMID:9353279</ref> <ref>PMID:12627223</ref> <ref>PMID:15113825</ref> <ref>PMID:16547010</ref> <ref>PMID:19939518</ref>
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[[https://www.uniprot.org/uniprot/HPGDS_HUMAN HPGDS_HUMAN]] Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.<ref>PMID:10824118</ref> <ref>PMID:11672424</ref> <ref>PMID:9425264</ref> <ref>PMID:9353279</ref> <ref>PMID:12627223</ref> <ref>PMID:15113825</ref> <ref>PMID:16547010</ref> <ref>PMID:19939518</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Glutathione S-transferase|Glutathione S-transferase]]
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*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Day, J E]]
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[[Category: Large Structures]]
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[[Category: Thorarensen, A]]
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[[Category: Day JE]]
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[[Category: Trujillo, J I]]
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[[Category: Thorarensen A]]
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[[Category: Inhibitor]]
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[[Category: Trujillo JI]]
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[[Category: Isomerase-isomerase inhibitor complex]]
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[[Category: Solvent replacement]]
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Revision as of 07:06, 28 September 2022

Crystal structure of hH-PGDS with water displacing inhibitor

PDB ID 4ee0

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