1mbm

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1mbm.jpg|left|200px]]
[[Image:1mbm.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1mbm |SIZE=350|CAPTION= <scene name='initialview01'>1mbm</scene>, resolution 2.00&Aring;
+
The line below this paragraph, containing "STRUCTURE_1mbm", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= NSP4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11047 Equine arteritis virus])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1mbm| PDB=1mbm | SCENE= }}
-
|RELATEDENTRY=[[1cqq|1CQQ]], [[1hav|1HAV]], [[1l1n|1L1N]], [[1hpg|1HPG]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mbm OCA], [http://www.ebi.ac.uk/pdbsum/1mbm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mbm RCSB]</span>
+
-
}}
+
'''NSP4 proteinase from Equine Arteritis Virus'''
'''NSP4 proteinase from Equine Arteritis Virus'''
Line 35: Line 32:
[[Category: Ng, K K.S.]]
[[Category: Ng, K K.S.]]
[[Category: Snijder, E J.]]
[[Category: Snijder, E J.]]
-
[[Category: chymotrypsin-like proteinase]]
+
[[Category: Chymotrypsin-like proteinase]]
-
[[Category: collapsed oxyanion hole]]
+
[[Category: Collapsed oxyanion hole]]
-
[[Category: serine proteinase]]
+
[[Category: Serine proteinase]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:51:44 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:14:04 2008''
+

Revision as of 21:51, 2 May 2008

Image:1mbm.jpg

Template:STRUCTURE 1mbm

NSP4 proteinase from Equine Arteritis Virus


Overview

Arteriviruses are enveloped, positive-stranded RNA viruses and include pathogens of major economic concern to the swine- and horse-breeding industries. The arterivirus replicase gene encodes two large precursor polyproteins that are processed by the viral main proteinase nonstructural protein 4 (nsp4). The three-dimensional structure of the 21-kDa nsp4 from the arterivirus prototype equine arteritis virus has been determined to 2.0 A resolution. Nsp4 adopts the smallest known chymotrypsin-like fold with a canonical catalytic triad of Ser-120, His-39, and Asp-65, as well as a novel alpha/beta C-terminal extension domain that may play a role in mediating protein-protein interactions. In different copies of nsp4 in the asymmetric unit, the oxyanion hole adopts either a collapsed inactive conformation or the standard active conformation, which may be a novel way of regulating proteolytic activity.

About this Structure

1MBM is a Single protein structure of sequence from Equine arteritis virus. Full crystallographic information is available from OCA.

Reference

Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an alpha/beta C-terminal extension and alternate conformations of the oxyanion hole., Barrette-Ng IH, Ng KK, Mark BL, Van Aken D, Cherney MM, Garen C, Kolodenko Y, Gorbalenya AE, Snijder EJ, James MN, J Biol Chem. 2002 Oct 18;277(42):39960-6. Epub 2002 Aug 5. PMID:12163505 Page seeded by OCA on Sat May 3 00:51:44 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1mbm"
Personal tools