1mdw

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[[Image:1mdw.gif|left|200px]]
[[Image:1mdw.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1mdw |SIZE=350|CAPTION= <scene name='initialview01'>1mdw</scene>, resolution 1.95&Aring;
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The line below this paragraph, containing "STRUCTURE_1mdw", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.52 and 3.4.22.53 3.4.22.52 and 3.4.22.53] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= CALPAIN II ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
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-->
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|DOMAIN=
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{{STRUCTURE_1mdw| PDB=1mdw | SCENE= }}
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|RELATEDENTRY=[[1kxr|1KXR]], [[1kfu|1KFU]], [[1kfx|1KFX]], [[1dfo|1DFO]], [[1aj5|1AJ5]], [[1alw|1ALW]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mdw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mdw OCA], [http://www.ebi.ac.uk/pdbsum/1mdw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mdw RCSB]</span>
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}}
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'''Crystal Structure of Calcium-Bound Protease Core of Calpain II Reveals the Basis for Intrinsic Inactivation'''
'''Crystal Structure of Calcium-Bound Protease Core of Calpain II Reveals the Basis for Intrinsic Inactivation'''
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[[Category: Lim, D.]]
[[Category: Lim, D.]]
[[Category: Moldoveanu, T.]]
[[Category: Moldoveanu, T.]]
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[[Category: calpain cysteine protease fold]]
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[[Category: Calpain cysteine protease fold]]
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[[Category: helix instability]]
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[[Category: Helix instability]]
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[[Category: tryptophan-based active site blockage]]
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[[Category: Tryptophan-based active site blockage]]
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[[Category: two cooperative calcium site]]
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[[Category: Two cooperative calcium site]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:55:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:14:51 2008''
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Revision as of 21:55, 2 May 2008

Image:1mdw.gif

Template:STRUCTURE 1mdw

Crystal Structure of Calcium-Bound Protease Core of Calpain II Reveals the Basis for Intrinsic Inactivation


Overview

Uncontrolled activation of calpain can lead to necrotic cell death and irreversible tissue damage. We have discovered an intrinsic mechanism whereby the autolysis-generated protease core fragment of calpain is inactivated through the inherent instability of a key alpha-helix. This auto-inactivation state was captured by the 1.9 A Ca(2+)-bound structure of the protease core from m-calpain, and sequence alignments suggest that it applies to about half of the calpain isoforms. Intact calpain large subunits are also subject to this inhibition, which can be prevented through assembly of the heterodimers. Other isoforms or their released cores are not silenced by this mechanism and might contribute to calpain patho-physiologies.

About this Structure

1MDW is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Calpain silencing by a reversible intrinsic mechanism., Moldoveanu T, Hosfield CM, Lim D, Jia Z, Davies PL, Nat Struct Biol. 2003 May;10(5):371-8. PMID:12665854 Page seeded by OCA on Sat May 3 00:55:33 2008

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