1me4
From Proteopedia
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'''High Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (I)''' | '''High Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (I)''' | ||
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[[Category: Ellman, J A.]] | [[Category: Ellman, J A.]] | ||
[[Category: Huang, L.]] | [[Category: Huang, L.]] | ||
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| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:55:57 2008'' | |
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Revision as of 21:55, 2 May 2008
High Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (I)
Overview
The crystal structures of two hydroxymethyl ketone inhibitors complexed to the cysteine protease cruzain have been determined at 1.1 and 1.2 A resolution, respectively. These high resolution crystal structures provide the first structures of non-covalent inhibitors bound to cruzain. A series of compounds were prepared and tested based upon the structures providing further insight into the key binding interactions.
About this Structure
1ME4 is a Single protein structure of sequence from Trypanosoma cruzi. Full crystallographic information is available from OCA.
Reference
Crystal structures of reversible ketone-Based inhibitors of the cysteine protease cruzain., Huang L, Brinen LS, Ellman JA, Bioorg Med Chem. 2003 Jan 2;11(1):21-9. PMID:12467703 Page seeded by OCA on Sat May 3 00:55:57 2008
