1mek

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[[Image:1mek.gif|left|200px]]
[[Image:1mek.gif|left|200px]]
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{{Structure
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|PDB= 1mek |SIZE=350|CAPTION= <scene name='initialview01'>1mek</scene>
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The line below this paragraph, containing "STRUCTURE_1mek", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_disulfide-isomerase Protein disulfide-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.4.1 5.3.4.1] </span>
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{{STRUCTURE_1mek| PDB=1mek | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mek OCA], [http://www.ebi.ac.uk/pdbsum/1mek PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mek RCSB]</span>
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'''HUMAN PROTEIN DISULFIDE ISOMERASE, NMR, 40 STRUCTURES'''
'''HUMAN PROTEIN DISULFIDE ISOMERASE, NMR, 40 STRUCTURES'''
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[[Category: Kemmink, J.]]
[[Category: Kemmink, J.]]
[[Category: Nilges, M.]]
[[Category: Nilges, M.]]
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[[Category: electron transport]]
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[[Category: Electron transport]]
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[[Category: endoplasmic reticulum]]
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[[Category: Endoplasmic reticulum]]
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[[Category: isomerase]]
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[[Category: Isomerase]]
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[[Category: redox-active center]]
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[[Category: Redox-active center]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:56:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:15:06 2008''
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Revision as of 21:56, 2 May 2008

Image:1mek.gif

Template:STRUCTURE 1mek

HUMAN PROTEIN DISULFIDE ISOMERASE, NMR, 40 STRUCTURES


Overview

As a first step in dissecting the structure of human protein disulfide isomerase (PDI), the structure of a fragment corresponding to the first 120 residues of its sequence has been determined using heteronuclear multidimensional NMR techniques. As expected from its primary structure homology, the fragment has the thioredoxin fold. Similarities and differences in their structures help to explain why thioredoxins are reductants, whereas PDI is an oxidant of protein thiol groups. The results confirm that PDI has a modular, multidomain structure, which will facilitate its structural and functional characterization.

About this Structure

1MEK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure determination of the N-terminal thioredoxin-like domain of protein disulfide isomerase using multidimensional heteronuclear 13C/15N NMR spectroscopy., Kemmink J, Darby NJ, Dijkstra K, Nilges M, Creighton TE, Biochemistry. 1996 Jun 18;35(24):7684-91. PMID:8672469 Page seeded by OCA on Sat May 3 00:56:41 2008

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