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1mee

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[[Image:1mee.gif|left|200px]]
[[Image:1mee.gif|left|200px]]
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{{Structure
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|PDB= 1mee |SIZE=350|CAPTION= <scene name='initialview01'>1mee</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1mee", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Subtilisin Subtilisin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.62 3.4.21.62] </span>
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{{STRUCTURE_1mee| PDB=1mee | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mee OCA], [http://www.ebi.ac.uk/pdbsum/1mee PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mee RCSB]</span>
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'''THE COMPLEX BETWEEN THE SUBTILISIN FROM A MESOPHILIC BACTERIUM AND THE LEECH INHIBITOR EGLIN-C'''
'''THE COMPLEX BETWEEN THE SUBTILISIN FROM A MESOPHILIC BACTERIUM AND THE LEECH INHIBITOR EGLIN-C'''
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[[Category: Dauter, Z.]]
[[Category: Dauter, Z.]]
[[Category: Wilson, K S.]]
[[Category: Wilson, K S.]]
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[[Category: complex(serine proteinase-inhibitor)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:56:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:15:02 2008''
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Revision as of 21:56, 2 May 2008

Image:1mee.gif

Template:STRUCTURE 1mee

THE COMPLEX BETWEEN THE SUBTILISIN FROM A MESOPHILIC BACTERIUM AND THE LEECH INHIBITOR EGLIN-C


Overview

The alkaline proteinase from the mesophilic bacterium Bacillus mesentericus has been crystallized in a 1:1 complex with the inhibitor eglin-C from the medical leech. The crystals have cell dimensions of a = 43.0, b = 71.9, c = 48.3 A and beta = 110.0 degrees and are in the space group P2(1). Three-dimensional data to 2.0 A have been recorded on film from a single crystal. The orientation and position of the complex in the unit cell have been established using the refined coordinates of subtilisin Carlsberg and of eglin-C as independent models. The structure of the complex has been refined by restrained least-squares minimization. The crystallographic R factor (= sigma[magnitude of Fo - magnitude of Fc[/sigma magnitude of Fo) is 15.1% including two Ca2+ ions and 312 water molecules. The structure is discussed in terms of its physicochemical properties in solution and its relation to other Bacillus subtilisins.

About this Structure

1MEE is a Protein complex structure of sequences from Bacillus pumilus and Hirudo medicinalis. Full crystallographic information is available from OCA.

Reference

Complex between the subtilisin from a mesophilic bacterium and the leech inhibitor eglin-C., Dauter Z, Betzel C, Genov N, Pipon N, Wilson KS, Acta Crystallogr B. 1991 Oct 1;47 ( Pt 5):707-30. PMID:1793542 Page seeded by OCA on Sat May 3 00:56:25 2008

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