1mh1

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[[Image:1mh1.jpg|left|200px]]
[[Image:1mh1.jpg|left|200px]]
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{{Structure
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|PDB= 1mh1 |SIZE=350|CAPTION= <scene name='initialview01'>1mh1</scene>, resolution 1.38&Aring;
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The line below this paragraph, containing "STRUCTURE_1mh1", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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|ACTIVITY=
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|GENE= RHO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1mh1| PDB=1mh1 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mh1 OCA], [http://www.ebi.ac.uk/pdbsum/1mh1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mh1 RCSB]</span>
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'''SMALL G-PROTEIN'''
'''SMALL G-PROTEIN'''
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[[Category: Stockley, R W.]]
[[Category: Stockley, R W.]]
[[Category: Webb, M R.]]
[[Category: Webb, M R.]]
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[[Category: gtp-binding]]
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[[Category: Gtp-binding]]
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[[Category: gtpase]]
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[[Category: Gtpase]]
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[[Category: ras super family]]
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[[Category: Ras super family]]
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[[Category: rho family]]
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[[Category: Rho family]]
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[[Category: small g-protein]]
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[[Category: Small g-protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 13:34:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:15:56 2008''
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Revision as of 10:34, 30 April 2008

Image:1mh1.jpg

Template:STRUCTURE 1mh1

SMALL G-PROTEIN


Contents

Overview

The crystal structure of human rac1, a member of the rho family of small G-proteins, complexed with the non-hydrolysable GTP analogue, guanosine-5'-(beta gamma-imino)triphosphate (GMPPNP), has been determined by X-ray analysis at a resolution of 1.38 A. Comparison with the structure of H-ras indicates that rac1 has an extra alpha-helical domain that is characteristic of the rho G proteins, and may be involved in the signalling pathway of this family.

Disease

Known disease associated with this structure: Night blindness, congenital stationery, rhodopsin-related OMIM:[180380], Retinitis pigmentosa, autosomal recessive OMIM:[180380], Retinitis pigmentosa-4, autosomal dominant OMIM:[180380]

About this Structure

1MH1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue., Hirshberg M, Stockley RW, Dodson G, Webb MR, Nat Struct Biol. 1997 Feb;4(2):147-52. PMID:9033596 Page seeded by OCA on Wed Apr 30 13:34:28 2008

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OCA

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