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1mhd

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[[Image:1mhd.gif|left|200px]]
[[Image:1mhd.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1mhd |SIZE=350|CAPTION= <scene name='initialview01'>1mhd</scene>, resolution 2.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1mhd", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= SMAD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1mhd| PDB=1mhd | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mhd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mhd OCA], [http://www.ebi.ac.uk/pdbsum/1mhd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mhd RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF A SMAD MH1 DOMAIN BOUND TO DNA'''
'''CRYSTAL STRUCTURE OF A SMAD MH1 DOMAIN BOUND TO DNA'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Shi, Y.]]
[[Category: Shi, Y.]]
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[[Category: complex (transcription activator/dna)]]
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[[Category: Dna]]
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[[Category: dna]]
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[[Category: Smad binding element]]
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[[Category: smad binding element]]
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[[Category: Smad3 mh1]]
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[[Category: smad3 mh1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:01:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:16:04 2008''
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Revision as of 22:01, 2 May 2008

Image:1mhd.gif

Template:STRUCTURE 1mhd

CRYSTAL STRUCTURE OF A SMAD MH1 DOMAIN BOUND TO DNA


Overview

The Smad family of proteins, which are frequently targeted by tumorigenic mutations in cancer, mediate TGF-beta signaling from cell membrane to nucleus. The crystal structure of a Smad3 MH1 domain bound to an optimal DNA sequence determined at 2.8 A resolution reveals a novel DNA-binding motif. In the crystals, base-specific DNA recognition is provided exclusively by a conserved 11-residue beta hairpin that is embedded in the major groove of DNA. A surface loop region, to which tumorigenic mutations map, has been identified as a functional surface important for Smad activity. This structure establishes a framework for understanding how Smad proteins may act in concert with other transcription factors in the regulation of TGF-beta-responsive genes.

About this Structure

1MHD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling., Shi Y, Wang YF, Jayaraman L, Yang H, Massague J, Pavletich NP, Cell. 1998 Sep 4;94(5):585-94. PMID:9741623 Page seeded by OCA on Sat May 3 01:01:50 2008

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