1mhe

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[[Image:1mhe.jpg|left|200px]]
[[Image:1mhe.jpg|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1mhe", creates the "Structure Box" on the page.
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|SITE=
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|GENE= HLA-E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), BETA-2-MICROGLOBULIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_1mhe| PDB=1mhe | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mhe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mhe OCA], [http://www.ebi.ac.uk/pdbsum/1mhe PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mhe RCSB]</span>
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'''THE HUMAN NON-CLASSICAL MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULE HLA-E'''
'''THE HUMAN NON-CLASSICAL MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULE HLA-E'''
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[[Category: Tormo, J.]]
[[Category: Tormo, J.]]
[[Category: Willcox, B E.]]
[[Category: Willcox, B E.]]
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[[Category: beta 2 microglobulin]]
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[[Category: Beta 2 microglobulin]]
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[[Category: class ib mhc]]
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[[Category: Class ib mhc]]
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[[Category: hla]]
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[[Category: Hla]]
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[[Category: hla e]]
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[[Category: Hla e]]
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[[Category: hla-e]]
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[[Category: Hla-e]]
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[[Category: leader peptide]]
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[[Category: Leader peptide]]
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[[Category: major histocompatibility complex]]
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[[Category: Major histocompatibility complex]]
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[[Category: mhc]]
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[[Category: Mhc]]
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[[Category: non-classical mhc]]
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[[Category: Non-classical mhc]]
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[[Category: peptide]]
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[[Category: Peptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:01:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:16:05 2008''
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Revision as of 22:01, 2 May 2008

Image:1mhe.jpg

Template:STRUCTURE 1mhe

THE HUMAN NON-CLASSICAL MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULE HLA-E


Overview

The crystal structure of the nonclassical human class lb MHC molecule HLA-E has been determined in complex with a prototypic ligand, the nonamer peptide (VMAPRTVLL), derived from the highly conserved residues 3-11 of the human MHC class la leader sequence. The mode of peptide binding retains some of the standard features observed in MHC class la complexes, but novel features imply that HLA-E has evolved to mediate specific binding to a tightly defined set of almost identical hydrophobic peptides from the highly conserved class l leader sequences. These molecular adaptations make HLA-E a rigorous checkpoint at the cell surface reporting on the integrity of the antigen processing pathway to CD94/NKG2 receptor-bearing natural killer cells.

About this Structure

1MHE is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E., O'Callaghan CA, Tormo J, Willcox BE, Braud VM, Jakobsen BK, Stuart DI, McMichael AJ, Bell JI, Jones EY, Mol Cell. 1998 Mar;1(4):531-41. PMID:9660937 Page seeded by OCA on Sat May 3 01:01:53 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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