2vlo

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==K97A MUTANT OF E9 DNASE DOMAIN IN COMPLEX WITH IM9==
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==K97A mutant of E9 DNase domain in complex with Im9==
<StructureSection load='2vlo' size='340' side='right' caption='[[2vlo]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='2vlo' size='340' side='right' caption='[[2vlo]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IMM9_ECOLX IMM9_ECOLX]] This protein is able to protect a cell, which harbors the plasmid ColE9 encoding colicin E9, against colicin E9, it binds specifically to the DNase-type colicin and inhibits its bactericidal activity. [[http://www.uniprot.org/uniprot/CEA9_ECOLX CEA9_ECOLX]] This plasmid-coded bactericidal protein is an endonuclease active on both single- and double-stranded DNA but with undefined specificity. Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria.
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[[http://www.uniprot.org/uniprot/IMM9_ECOLX IMM9_ECOLX]] This protein is able to protect a cell, which harbors the plasmid ColE9 encoding colicin E9, against colicin E9, it binds specifically to the DNase-type colicin and inhibits its bactericidal activity.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vl/2vlo_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vl/2vlo_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Metal-binding]]
[[Category: Metal-binding]]
[[Category: Nuclease]]
[[Category: Nuclease]]
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[[Category: Plasmid]]
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[[Category: Protein binding]]
[[Category: Protein-binding]]
[[Category: Protein-binding]]
[[Category: Protein-protein interaction]]
[[Category: Protein-protein interaction]]
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[[Category: Zinc]]

Revision as of 21:11, 19 September 2018

K97A mutant of E9 DNase domain in complex with Im9

2vlo, resolution 1.80Å

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