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4k47

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==Structure of the Streptococcus pneumoniae leucyl-tRNA synthetase editing domain bound to a benzoxaborole-AMP adduct==
==Structure of the Streptococcus pneumoniae leucyl-tRNA synthetase editing domain bound to a benzoxaborole-AMP adduct==
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<StructureSection load='4k47' size='340' side='right' caption='[[4k47]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
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<StructureSection load='4k47' size='340' side='right'caption='[[4k47]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4k47]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strpj Strpj]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K47 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K47 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4k47]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_ATCC_700669 Streptococcus pneumoniae ATCC 700669]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K47 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K47 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=WMP:[(1R,5R,6R,8S)-6-(6-AMINOPURIN-9-YL)-3-[(R)-OXIDANYL(PHENYL)METHYL]SPIRO[2,4,7-TRIOXA-3-BORANUIDABICYCLO[3.3.0]OCTANE-3,9-8-OXA-9-BORANUIDABICYCLO[4.3.0]NONA-1,3,5-TRIENE]-8-YL]METHYL+DIHYDROGEN+PHOSPHATE'>WMP</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=WMP:[(1R,5R,6R,8S)-6-(6-AMINOPURIN-9-YL)-3-[(R)-OXIDANYL(PHENYL)METHYL]SPIRO[2,4,7-TRIOXA-3-BORANUIDABICYCLO[3.3.0]OCTANE-3,9-8-OXA-9-BORANUIDABICYCLO[4.3.0]NONA-1,3,5-TRIENE]-8-YL]METHYL+DIHYDROGEN+PHOSPHATE'>WMP</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4k48|4k48]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k47 OCA], [https://pdbe.org/4k47 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k47 RCSB], [https://www.ebi.ac.uk/pdbsum/4k47 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k47 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">leuS, SPN23F02440 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=561276 STRPJ])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leucine--tRNA_ligase Leucine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.4 6.1.1.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k47 OCA], [http://pdbe.org/4k47 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4k47 RCSB], [http://www.ebi.ac.uk/pdbsum/4k47 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4k47 ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SYL_STRPJ SYL_STRPJ]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4k47" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4k47" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Leucine--tRNA ligase]]
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[[Category: Large Structures]]
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[[Category: Strpj]]
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[[Category: Streptococcus pneumoniae ATCC 700669]]
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[[Category: Ding, Y Y]]
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[[Category: Ding YY]]
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[[Category: Fang, Z P]]
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[[Category: Fang ZP]]
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[[Category: Hu, Q H]]
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[[Category: Hu QH]]
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[[Category: Liu, R J]]
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[[Category: Liu RJ]]
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[[Category: Pan, W]]
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[[Category: Pan W]]
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[[Category: Tan, M]]
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[[Category: Tan M]]
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[[Category: Wang, E D]]
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[[Category: Wang ED]]
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[[Category: Wang, M]]
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[[Category: Wang M]]
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[[Category: Zhang, J]]
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[[Category: Zhang J]]
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[[Category: Zhou, H C]]
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[[Category: Zhou HC]]
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[[Category: Antibacterial]]
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[[Category: Benzoxaborole]]
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[[Category: Leucyl-trna synthetase]]
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[[Category: Ligase-ligase inhibitor complex]]
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Revision as of 11:39, 30 November 2022

Structure of the Streptococcus pneumoniae leucyl-tRNA synthetase editing domain bound to a benzoxaborole-AMP adduct

PDB ID 4k47

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