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4iwn

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==Crystal structure of a putative methyltransferase CmoA in complex with a novel SAM derivative==
==Crystal structure of a putative methyltransferase CmoA in complex with a novel SAM derivative==
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<StructureSection load='4iwn' size='340' side='right' caption='[[4iwn]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
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<StructureSection load='4iwn' size='340' side='right'caption='[[4iwn]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4iwn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IWN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4iwn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IWN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IWN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GEK:(2S)-4-[{[(2S,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL}(CARBOXYLATOMETHYL)SULFONIO]-2-AMMONIOBUTANOATE'>GEK</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GEK:(2S)-4-[{[(2S,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL}(CARBOXYLATOMETHYL)SULFONIO]-2-AMMONIOBUTANOATE'>GEK</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cmoA, yecO, b1870, JW1859 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iwn OCA], [https://pdbe.org/4iwn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iwn RCSB], [https://www.ebi.ac.uk/pdbsum/4iwn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iwn ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iwn OCA], [http://pdbe.org/4iwn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4iwn RCSB], [http://www.ebi.ac.uk/pdbsum/4iwn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4iwn ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CMOA_ECOLI CMOA_ECOLI]] Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity).
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[https://www.uniprot.org/uniprot/CMOA_ECOLI CMOA_ECOLI] Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[TRNA methyltransferase|TRNA methyltransferase]]
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*[[TRNA methyltransferase 3D structures|TRNA methyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: Aller, P]]
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[[Category: Large Structures]]
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[[Category: Antson, A A]]
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[[Category: Aller P]]
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[[Category: Byrne, R T]]
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[[Category: Antson AA]]
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[[Category: Lobley, C M]]
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[[Category: Byrne RT]]
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[[Category: Waterman, D G]]
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[[Category: Lobley CM]]
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[[Category: Putative trna modification enzyme]]
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[[Category: Waterman DG]]
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[[Category: Scm-sah]]
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[[Category: Transferase]]
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Revision as of 21:16, 16 November 2022

Crystal structure of a putative methyltransferase CmoA in complex with a novel SAM derivative

PDB ID 4iwn

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