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4hz5

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==Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity==
==Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity==
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<StructureSection load='4hz5' size='340' side='right' caption='[[4hz5]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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<StructureSection load='4hz5' size='340' side='right'caption='[[4hz5]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4hz5]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Entfa Entfa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HZ5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4hz5]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis_V583 Enterococcus faecalis V583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HZ5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=19Y:6-ETHYL-4-METHOXY-2-(PYRIDIN-3-YLSULFANYL)-7H-PYRROLO[2,3-D]PYRIMIDINE-5-CARBALDEHYDE'>19Y</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=19Y:6-ETHYL-4-METHOXY-2-(PYRIDIN-3-YLSULFANYL)-7H-PYRROLO[2,3-D]PYRIMIDINE-5-CARBALDEHYDE'>19Y</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4hz0|4hz0]], [[4hyp|4hyp]], [[4hym|4hym]], [[4hy1|4hy1]], [[4hxz|4hxz]], [[4ggl|4ggl]], [[4gfn|4gfn]], [[4gee|4gee]], [[4hxw|4hxw]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hz5 OCA], [https://pdbe.org/4hz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hz5 RCSB], [https://www.ebi.ac.uk/pdbsum/4hz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hz5 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">parE, EF_1615 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=226185 ENTFA])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hz5 OCA], [http://pdbe.org/4hz5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hz5 RCSB], [http://www.ebi.ac.uk/pdbsum/4hz5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hz5 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/H7C794_ENTFA H7C794_ENTFA]] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.[HAMAP-Rule:MF_00939]
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[https://www.uniprot.org/uniprot/PARE_ENTFA PARE_ENTFA] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA (PubMed:23352267). Performs the decatenation events required during the replication of a circular DNA molecule.[HAMAP-Rule:MF_00938]<ref>PMID:23352267</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Topoisomerase|Topoisomerase]]
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*[[Topoisomerase 3D structures|Topoisomerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Entfa]]
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[[Category: Enterococcus faecalis V583]]
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[[Category: Bensen, D C]]
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[[Category: Large Structures]]
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[[Category: Creighton, C J]]
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[[Category: Bensen DC]]
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[[Category: Tari, L W]]
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[[Category: Creighton CJ]]
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[[Category: Atp-binding]]
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[[Category: Tari LW]]
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[[Category: Atp-binding domain]]
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[[Category: Isomerase-isomerase inhibitor complex]]
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[[Category: Nucleotide-binding]]
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[[Category: Topoisomerase]]
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Revision as of 08:28, 9 November 2022

Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity

PDB ID 4hz5

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