3pxi

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==Structure of MecA108:ClpC==
==Structure of MecA108:ClpC==
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<StructureSection load='3pxi' size='340' side='right' caption='[[3pxi]], [[Resolution|resolution]] 6.93&Aring;' scene=''>
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<StructureSection load='3pxi' size='340' side='right'caption='[[3pxi]], [[Resolution|resolution]] 6.93&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3pxi]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PXI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PXI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3pxi]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PXI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PXI FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2y1q|2y1q]], [[2y1r|2y1r]], [[3pxg|3pxg]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2y1q|2y1q]], [[2y1r|2y1r]], [[3pxg|3pxg]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mecA, BSU11520 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Bacillus globigii" Migula 1900]), clpC, mecB, BSU00860 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Bacillus globigii" Migula 1900])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mecA, BSU11520 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835]), clpC, mecB, BSU00860 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pxi OCA], [http://pdbe.org/3pxi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3pxi RCSB], [http://www.ebi.ac.uk/pdbsum/3pxi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3pxi ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pxi OCA], [https://pdbe.org/3pxi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pxi RCSB], [https://www.ebi.ac.uk/pdbsum/3pxi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pxi ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MECA1_BACSU MECA1_BACSU]] Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC.<ref>PMID:12598648</ref> [[http://www.uniprot.org/uniprot/CLPC_BACSU CLPC_BACSU]] Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with MecA to negatively regulate comK.
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[[https://www.uniprot.org/uniprot/MECA1_BACSU MECA1_BACSU]] Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC.<ref>PMID:12598648</ref> [[https://www.uniprot.org/uniprot/CLPC_BACSU CLPC_BACSU]] Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with MecA to negatively regulate comK.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus globigii migula 1900]]
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[[Category: Vibrio subtilis ehrenberg 1835]]
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[[Category: Large Structures]]
[[Category: Mei, Z Q]]
[[Category: Mei, Z Q]]
[[Category: Shi, Y G]]
[[Category: Shi, Y G]]

Revision as of 09:00, 25 May 2022

Structure of MecA108:ClpC

PDB ID 3pxi

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