3uyp
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Crystal structure of the dengue virus serotype 4 envelope protein domain III in complex with the variable domains of Mab 4E11== | ==Crystal structure of the dengue virus serotype 4 envelope protein domain III in complex with the variable domains of Mab 4E11== | ||
| - | <StructureSection load='3uyp' size='340' side='right' caption='[[3uyp]], [[Resolution|resolution]] 2.00Å' scene=''> | + | <StructureSection load='3uyp' size='340' side='right'caption='[[3uyp]], [[Resolution|resolution]] 2.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3uyp]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3uyp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_4 Dengue virus 4] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UYP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UYP FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3uze|3uze]], [[3uzq|3uzq]], [[3uzv|3uzv]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3uze|3uze]], [[3uzq|3uzq]], [[3uzv|3uzv]]</div></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uyp OCA], [https://pdbe.org/3uyp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uyp RCSB], [https://www.ebi.ac.uk/pdbsum/3uyp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uyp ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/Q9IZJ0_9FLAV Q9IZJ0_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774] |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 24: | Line 24: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Dengue virus 4]] | [[Category: Dengue virus 4]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Lk3 transgenic mice]] | [[Category: Lk3 transgenic mice]] | ||
[[Category: Bedouelle, H]] | [[Category: Bedouelle, H]] | ||
Revision as of 08:16, 20 July 2022
Crystal structure of the dengue virus serotype 4 envelope protein domain III in complex with the variable domains of Mab 4E11
| |||||||||||
