3pth

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==The PABC1 MLLE domain bound to the variant PAM2 motif of LARP4B==
==The PABC1 MLLE domain bound to the variant PAM2 motif of LARP4B==
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<StructureSection load='3pth' size='340' side='right' caption='[[3pth]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='3pth' size='340' side='right'caption='[[3pth]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3pth]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PTH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PTH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3pth]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PTH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PTH FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PABPC1, PAB1, PABP1, PABPC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PABPC1, PAB1, PABP1, PABPC2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pth OCA], [http://pdbe.org/3pth PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3pth RCSB], [http://www.ebi.ac.uk/pdbsum/3pth PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3pth ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pth OCA], [https://pdbe.org/3pth PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pth RCSB], [https://www.ebi.ac.uk/pdbsum/3pth PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pth ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PABP1_HUMAN PABP1_HUMAN]] Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed.<ref>PMID:11051545</ref> <ref>PMID:18447585</ref> [[http://www.uniprot.org/uniprot/LAR4B_HUMAN LAR4B_HUMAN]] Stimulates mRNA translation.<ref>PMID:20573744</ref>
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[[https://www.uniprot.org/uniprot/PABP1_HUMAN PABP1_HUMAN]] Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed.<ref>PMID:11051545</ref> <ref>PMID:18447585</ref> [[https://www.uniprot.org/uniprot/LAR4B_HUMAN LAR4B_HUMAN]] Stimulates mRNA translation.<ref>PMID:20573744</ref>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Grimm, C]]
[[Category: Grimm, C]]
[[Category: Pelz, J P]]
[[Category: Pelz, J P]]
[[Category: Mlle domain]]
[[Category: Mlle domain]]
[[Category: Rna binding protein]]
[[Category: Rna binding protein]]

Revision as of 08:54, 25 May 2022

The PABC1 MLLE domain bound to the variant PAM2 motif of LARP4B

PDB ID 3pth

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