1mjg

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[[Image:1mjg.gif|left|200px]]
[[Image:1mjg.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1mjg |SIZE=350|CAPTION= <scene name='initialview01'>1mjg</scene>, resolution 2.2&Aring;
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The line below this paragraph, containing "STRUCTURE_1mjg", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CU1:COPPER+(I)+ION'>CU1</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=XCC:FE(4)-NI(1)-S(4)+CLUSTER'>XCC</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbon-monoxide_dehydrogenase_(acceptor) Carbon-monoxide dehydrogenase (acceptor)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.99.2 1.2.99.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1mjg| PDB=1mjg | SCENE= }}
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|RELATEDENTRY=[[1jqk|1JQK]], [[1jjy|1JJY]], [[1e9v|1E9V]], [[1e2u|1E2U]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mjg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mjg OCA], [http://www.ebi.ac.uk/pdbsum/1mjg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mjg RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF BIFUNCTIONAL CARBON MONOXIDE DEHYDROGENASE/ACETYL-COA SYNTHASE(CODH/ACS) FROM MOORELLA THERMOACETICA (F. CLOSTRIDIUM THERMOACETICUM)'''
'''CRYSTAL STRUCTURE OF BIFUNCTIONAL CARBON MONOXIDE DEHYDROGENASE/ACETYL-COA SYNTHASE(CODH/ACS) FROM MOORELLA THERMOACETICA (F. CLOSTRIDIUM THERMOACETICUM)'''
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==Reference==
==Reference==
A Ni-Fe-Cu center in a bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase., Doukov TI, Iverson TM, Seravalli J, Ragsdale SW, Drennan CL, Science. 2002 Oct 18;298(5593):567-72. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12386327 12386327]
A Ni-Fe-Cu center in a bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase., Doukov TI, Iverson TM, Seravalli J, Ragsdale SW, Drennan CL, Science. 2002 Oct 18;298(5593):567-72. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12386327 12386327]
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[[Category: Carbon-monoxide dehydrogenase (acceptor)]]
 
[[Category: Moorella thermoacetica]]
[[Category: Moorella thermoacetica]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Ragsdale, S W.]]
[[Category: Ragsdale, S W.]]
[[Category: Seravalli, J.]]
[[Category: Seravalli, J.]]
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[[Category: acetyl-coa synthase (acs)]]
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[[Category: Clostridium thermoaceticum]]
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[[Category: carbon monoxide dehydrogenase(codh)]]
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[[Category: Electron transfer]]
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[[Category: clostridium thermoaceticum]]
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[[Category: Helical domain]]
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[[Category: electron transfer]]
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[[Category: Hydrophobic co channel]]
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[[Category: helical domain]]
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[[Category: Rossmann fold]]
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[[Category: hydrophobic co channel]]
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[[Category: Substrate tunnel]]
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[[Category: nickel-coopper-iron-sulfur (ni-cu-fe-s) cluster]]
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[[Category: Wood-ljundahl pathway]]
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[[Category: nickel-iron-sulfur cluster (ni-fe-s)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:11:18 2008''
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[[Category: rossmann fold]]
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[[Category: substrate tunnel]]
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[[Category: wood-ljundahl pathway,]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:16:52 2008''
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Revision as of 22:11, 2 May 2008

Image:1mjg.gif

Template:STRUCTURE 1mjg

CRYSTAL STRUCTURE OF BIFUNCTIONAL CARBON MONOXIDE DEHYDROGENASE/ACETYL-COA SYNTHASE(CODH/ACS) FROM MOORELLA THERMOACETICA (F. CLOSTRIDIUM THERMOACETICUM)


Overview

A metallocofactor containing iron, sulfur, copper, and nickel has been discovered in the enzyme carbon monoxide dehydrogenase/acetyl-CoA (coenzyme A) synthase from Moorella thermoacetica (f. Clostridium thermoaceticum). Our structure at 2.2 angstrom resolution reveals that the cofactor responsible for the assembly of acetyl-CoA contains a [Fe4S4] cubane bridged to a copper-nickel binuclear site. The presence of these three metals together in one cluster was unanticipated and suggests a newly discovered role for copper in biology. The different active sites of this bifunctional enzyme complex are connected via a channel, 138 angstroms long, that provides a conduit for carbon monoxide generated at the C-cluster on one subunit to be incorporated into acetyl-CoA at the A-cluster on the other subunit.

About this Structure

1MJG is a Protein complex structure of sequences from Moorella thermoacetica. Full crystallographic information is available from OCA.

Reference

A Ni-Fe-Cu center in a bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase., Doukov TI, Iverson TM, Seravalli J, Ragsdale SW, Drennan CL, Science. 2002 Oct 18;298(5593):567-72. PMID:12386327 Page seeded by OCA on Sat May 3 01:11:18 2008

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