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4g9z

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==Lassa nucleoprotein with dsRNA reveals novel mechanism for immune suppression==
==Lassa nucleoprotein with dsRNA reveals novel mechanism for immune suppression==
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<StructureSection load='4g9z' size='340' side='right' caption='[[4g9z]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
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<StructureSection load='4g9z' size='340' side='right'caption='[[4g9z]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4g9z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lassj Lassj]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G9Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G9Z FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4g9z]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lassa_virus_Josiah Lassa virus Josiah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G9Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G9Z FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3mwp|3mwp]], [[3mx5|3mx5]], [[3mx2|3mx2]], [[3mwt|3mwt]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g9z OCA], [https://pdbe.org/4g9z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g9z RCSB], [https://www.ebi.ac.uk/pdbsum/4g9z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g9z ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">N ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11622 LASSJ])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g9z OCA], [http://pdbe.org/4g9z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g9z RCSB], [http://www.ebi.ac.uk/pdbsum/4g9z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g9z ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NCAP_LASSJ NCAP_LASSJ]] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFN-beta) production. Strongly inhibits the nuclear translocation of IRF3, a protein involved in IFN activation pathway. Also inhibits the activation of IFN-beta and IRF3-dependent promoters (By similarity).
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[https://www.uniprot.org/uniprot/NCAP_LASSJ NCAP_LASSJ] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFN-beta) production. Strongly inhibits the nuclear translocation of IRF3, a protein involved in IFN activation pathway. Also inhibits the activation of IFN-beta and IRF3-dependent promoters (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Nucleoprotein|Nucleoprotein]]
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*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lassj]]
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[[Category: Large Structures]]
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[[Category: Dong, C]]
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[[Category: Lassa virus Josiah]]
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[[Category: Dong, H]]
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[[Category: Dong C]]
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[[Category: Huang, Q]]
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[[Category: Dong H]]
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[[Category: Jiang, X]]
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[[Category: Huang Q]]
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[[Category: Liang, Y]]
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[[Category: Jiang X]]
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[[Category: Ly, H]]
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[[Category: Liang Y]]
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[[Category: SSPF, Scottish Structural Proteomics Facility]]
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[[Category: Ly H]]
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[[Category: Wang, W]]
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[[Category: Wang W]]
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[[Category: 3'-5'-ribonuclease]]
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[[Category: Nuclease]]
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[[Category: Scottish structural proteomics facility]]
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[[Category: Sspf]]
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[[Category: Structural genomic]]
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[[Category: Viral protein-rna complex]]
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Revision as of 06:44, 26 October 2022

Lassa nucleoprotein with dsRNA reveals novel mechanism for immune suppression

PDB ID 4g9z

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