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4dkf

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Current revision (08:22, 21 September 2022) (edit) (undo)
 
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==Crystal Structure of Human Interleukin-34 Bound to FAb2==
==Crystal Structure of Human Interleukin-34 Bound to FAb2==
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<StructureSection load='4dkf' size='340' side='right' caption='[[4dkf]], [[Resolution|resolution]] 2.61&Aring;' scene=''>
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<StructureSection load='4dkf' size='340' side='right'caption='[[4dkf]], [[Resolution|resolution]] 2.61&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4dkf]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DKF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DKF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4dkf]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DKF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4dkc|4dkc]], [[4dkd|4dkd]], [[4dke|4dke]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dkf OCA], [https://pdbe.org/4dkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dkf RCSB], [https://www.ebi.ac.uk/pdbsum/4dkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dkf ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IL34, C16orf77 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dkf OCA], [http://pdbe.org/4dkf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4dkf RCSB], [http://www.ebi.ac.uk/pdbsum/4dkf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4dkf ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IL34_HUMAN IL34_HUMAN]] Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.<ref>PMID:18467591</ref> <ref>PMID:20489731</ref> <ref>PMID:20829061</ref> <ref>PMID:20504948</ref>
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[[https://www.uniprot.org/uniprot/IL34_HUMAN IL34_HUMAN]] Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.<ref>PMID:18467591</ref> <ref>PMID:20489731</ref> <ref>PMID:20829061</ref> <ref>PMID:20504948</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Interleukin|Interleukin]]
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*[[Interleukin 3D structures|Interleukin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Bazan, J F]]
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[[Category: Large Structures]]
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[[Category: Chen, Y]]
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[[Category: Bazan JF]]
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[[Category: Ma, X]]
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[[Category: Chen Y]]
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[[Category: Starovasnik, M A]]
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[[Category: Ma X]]
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[[Category: Stawicki, S]]
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[[Category: Starovasnik MA]]
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[[Category: Wu, Y]]
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[[Category: Stawicki S]]
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[[Category: Cytokine-immune system complex]]
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[[Category: Wu Y]]
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[[Category: Dimeric four-helix bundle cytokine]]
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[[Category: Glycosylation]]
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[[Category: Igg]]
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Current revision

Crystal Structure of Human Interleukin-34 Bound to FAb2

PDB ID 4dkf

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