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1mky

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[[Image:1mky.jpg|left|200px]]
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|LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mky OCA], [http://www.ebi.ac.uk/pdbsum/1mky PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mky RCSB]</span>
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'''Structural Analysis of the Domain Interactions in Der, a Switch Protein Containing Two GTPase Domains'''
'''Structural Analysis of the Domain Interactions in Der, a Switch Protein Containing Two GTPase Domains'''
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[[Category: Robinson, V L.]]
[[Category: Robinson, V L.]]
[[Category: Stock, A M.]]
[[Category: Stock, A M.]]
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[[Category: der]]
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[[Category: Der]]
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[[Category: enga]]
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[[Category: Enga]]
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[[Category: gtpase]]
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[[Category: Gtpase]]
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[[Category: kh-domain]]
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[[Category: Kh-domain]]
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[[Category: tandem g-domain]]
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[[Category: Tandem g-domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:20:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:17:33 2008''
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Revision as of 22:20, 2 May 2008

Image:1mky.jpg

Template:STRUCTURE 1mky

Structural Analysis of the Domain Interactions in Der, a Switch Protein Containing Two GTPase Domains


Overview

The EngA subfamily of essential bacterial GTPases has a unique domain structure consisting of two adjacent GTPase domains (GD1 and GD2) and a C-terminal domain. The structure of Thermotoga maritima Der bound to GDP determined at 1.9 A resolution reveals a novel domain arrangement in which the GTPase domains pack at either side of the C-terminal domain. Unexpectedly, the C-terminal domain resembles a KH domain, missing the distinctive RNA recognition elements. Conserved motifs of the nucleotide binding site of GD1 are integral parts of the GD1-KH domain interface, suggesting the interactions between these two domains are directly influenced by the GTP/GDP cycling of the protein. In contrast, the GD2-KH domain interface is distal to the GDP binding site of GD2.

About this Structure

1MKY is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Domain arrangement of Der, a switch protein containing two GTPase domains., Robinson VL, Hwang J, Fox E, Inouye M, Stock AM, Structure. 2002 Dec;10(12):1649-58. PMID:12467572 Page seeded by OCA on Sat May 3 01:20:42 2008

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