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4hur

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==Crystal structure of streptogramin group A antibiotic acetyltransferase VatA from Staphylococcus aureus in complex with acetyl coenzyme A==
==Crystal structure of streptogramin group A antibiotic acetyltransferase VatA from Staphylococcus aureus in complex with acetyl coenzyme A==
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<StructureSection load='4hur' size='340' side='right' caption='[[4hur]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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<StructureSection load='4hur' size='340' side='right'caption='[[4hur]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4hur]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HUR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HUR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4hur]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HUR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HUR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4hus|4hus]], [[4e8l|4e8l]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hur OCA], [https://pdbe.org/4hur PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hur RCSB], [https://www.ebi.ac.uk/pdbsum/4hur PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hur ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">vat ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hur OCA], [http://pdbe.org/4hur PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hur RCSB], [http://www.ebi.ac.uk/pdbsum/4hur PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hur ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/VATA_STAAU VATA_STAAU]] Inactivates the A compounds of virginiamycin-like antibiotics, thus providing resistance to these antibiotics.
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[https://www.uniprot.org/uniprot/VATA_STAAU VATA_STAAU] Inactivates the A compounds of virginiamycin-like antibiotics, thus providing resistance to these antibiotics.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Anderson, W F]]
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[[Category: Large Structures]]
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[[Category: Structural genomic]]
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[[Category: Staphylococcus aureus]]
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[[Category: Courvalin, P]]
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[[Category: Anderson WF]]
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[[Category: Evdokimova, E]]
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[[Category: Courvalin P]]
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[[Category: Krishnamoorthy, M]]
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[[Category: Di Leo R]]
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[[Category: Leo, R Di]]
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[[Category: Evdokimova E]]
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[[Category: Minasov, G]]
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[[Category: Krishnamoorthy M]]
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[[Category: Savchenko, A]]
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[[Category: Minasov G]]
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[[Category: Stogios, P J]]
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[[Category: Savchenko A]]
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[[Category: Wawrzak, Z]]
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[[Category: Stogios PJ]]
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[[Category: Yim, V]]
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[[Category: Wawrzak Z]]
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[[Category: Acetyl coenzyme some]]
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[[Category: Yim V]]
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[[Category: Antibiotic resistance]]
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[[Category: Coenzyme some]]
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[[Category: Dalfopristin]]
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[[Category: Hexapeptide repeat acyltransferase]]
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[[Category: Intracellular]]
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[[Category: National institute of allergy and infectious disease]]
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[[Category: Niaid]]
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[[Category: Streptogramin some]]
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[[Category: Streptogramin group a antibiotic acetyltransferase]]
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[[Category: Streptogramin group a antibiotic]]
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[[Category: Transferase]]
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[[Category: Virginiamycin m1]]
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Revision as of 08:16, 9 November 2022

Crystal structure of streptogramin group A antibiotic acetyltransferase VatA from Staphylococcus aureus in complex with acetyl coenzyme A

PDB ID 4hur

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