1moz
From Proteopedia
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'''ADP-ribosylation factor-like 1 (ARL1) from Saccharomyces cerevisiae''' | '''ADP-ribosylation factor-like 1 (ARL1) from Saccharomyces cerevisiae''' | ||
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[[Category: Wang, Y.]] | [[Category: Wang, Y.]] | ||
[[Category: Zhu, X.]] | [[Category: Zhu, X.]] | ||
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Revision as of 22:32, 2 May 2008
ADP-ribosylation factor-like 1 (ARL1) from Saccharomyces cerevisiae
Overview
Structures were determined by x-ray crystallography for two members of the ADP-ribosylation factor (ARF) family of regulatory GTPases, yeast ARF1 and ARL1, and were compared with previously determined structures of human ARF1 and ARF6. These analyses revealed an overall conserved fold but differences in primary sequence and length, particularly in an N-terminal loop, lead to differences in nucleotide and divalent metal binding. Packing of hydrophobic residues is central to the interplay between the N-terminal alpha-helix, switch I, and the interswitch region, which along with differences in surface electrostatics provide explanations for the different biophysical and biochemical properties of ARF and ARF-like proteins.
About this Structure
1MOZ is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
Structures of yeast ARF2 and ARL1: distinct roles for the N terminus in the structure and function of ARF family GTPases., Amor JC, Horton JR, Zhu X, Wang Y, Sullards C, Ringe D, Cheng X, Kahn RA, J Biol Chem. 2001 Nov 9;276(45):42477-84. Epub 2001 Sep 4. PMID:11535602 Page seeded by OCA on Sat May 3 01:32:28 2008
