1mpu
From Proteopedia
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'''Crystal Structure of the free human NKG2D immunoreceptor''' | '''Crystal Structure of the free human NKG2D immunoreceptor''' | ||
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[[Category: McFarland, B J.]] | [[Category: McFarland, B J.]] | ||
[[Category: Strong, R K.]] | [[Category: Strong, R K.]] | ||
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Revision as of 22:34, 2 May 2008
Crystal Structure of the free human NKG2D immunoreceptor
Overview
Engagement of diverse protein ligands (MIC-A/B, ULBP, Rae-1, or H60) by NKG2D immunoreceptors mediates elimination of tumorigenic or virally infected cells by natural killer and T cells. Three previous NKG2D-ligand complex structures show the homodimeric receptor interacting with the monomeric ligands in similar 2:1 complexes, with an equivalent surface on each NKG2D monomer binding intimately to a total of six distinct ligand surfaces. Here, the crystal structure of free human NKG2D and in silico and in vitro alanine-scanning mutagenesis analyses of the complex interfaces indicate that NKG2D recognition degeneracy is not explained by a classical induced-fit mechanism. Rather, the divergent ligands appear to utilize different strategies to interact with structurally conserved elements of the consensus NKG2D binding site.
About this Structure
1MPU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Symmetry recognizing asymmetry: analysis of the interactions between the C-type lectin-like immunoreceptor NKG2D and MHC class I-like ligands., McFarland BJ, Kortemme T, Yu SF, Baker D, Strong RK, Structure. 2003 Apr;11(4):411-22. PMID:12679019 Page seeded by OCA on Sat May 3 01:34:16 2008
