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2y0b

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==Caspase-3 in Complex with an Inhibitory DARPin-3.4_S76R==
==Caspase-3 in Complex with an Inhibitory DARPin-3.4_S76R==
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<StructureSection load='2y0b' size='340' side='right' caption='[[2y0b]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='2y0b' size='340' side='right'caption='[[2y0b]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2y0b]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Miscellaneous_nucleic_acid Miscellaneous nucleic acid]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y0B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y0B FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2y0b]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Miscellaneous_nucleic_acid Miscellaneous nucleic acid]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y0B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y0B FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xzd|2xzd]], [[1rhk|1rhk]], [[1rhq|1rhq]], [[2dko|2dko]], [[2xyp|2xyp]], [[2j31|2j31]], [[2cjy|2cjy]], [[2xyh|2xyh]], [[2cjx|2cjx]], [[1re1|1re1]], [[2xyg|2xyg]], [[2c1e|2c1e]], [[2cno|2cno]], [[1gfw|1gfw]], [[1qx3|1qx3]], [[1rhm|1rhm]], [[1nme|1nme]], [[2j33|2j33]], [[1rhr|1rhr]], [[1nms|1nms]], [[1nmq|1nmq]], [[1rhj|1rhj]], [[2cnn|2cnn]], [[2c2k|2c2k]], [[2cnl|2cnl]], [[2c2m|2c2m]], [[1cp3|1cp3]], [[2cnk|2cnk]], [[2j30|2j30]], [[1pau|1pau]], [[2xzt|2xzt]], [[2cdr|2cdr]], [[1i3o|1i3o]], [[2j32|2j32]], [[1rhu|1rhu]], [[2c2o|2c2o]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xzd|2xzd]], [[1rhk|1rhk]], [[1rhq|1rhq]], [[2dko|2dko]], [[2xyp|2xyp]], [[2j31|2j31]], [[2cjy|2cjy]], [[2xyh|2xyh]], [[2cjx|2cjx]], [[1re1|1re1]], [[2xyg|2xyg]], [[2c1e|2c1e]], [[2cno|2cno]], [[1gfw|1gfw]], [[1qx3|1qx3]], [[1rhm|1rhm]], [[1nme|1nme]], [[2j33|2j33]], [[1rhr|1rhr]], [[1nms|1nms]], [[1nmq|1nmq]], [[1rhj|1rhj]], [[2cnn|2cnn]], [[2c2k|2c2k]], [[2cnl|2cnl]], [[2c2m|2c2m]], [[1cp3|1cp3]], [[2cnk|2cnk]], [[2j30|2j30]], [[1pau|1pau]], [[2xzt|2xzt]], [[2cdr|2cdr]], [[1i3o|1i3o]], [[2j32|2j32]], [[1rhu|1rhu]], [[2c2o|2c2o]]</div></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-3 Caspase-3], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.56 3.4.22.56] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Caspase-3 Caspase-3], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.56 3.4.22.56] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y0b OCA], [http://pdbe.org/2y0b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y0b RCSB], [http://www.ebi.ac.uk/pdbsum/2y0b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y0b ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y0b OCA], [https://pdbe.org/2y0b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y0b RCSB], [https://www.ebi.ac.uk/pdbsum/2y0b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y0b ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>
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[[https://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Caspase|Caspase]]
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*[[Caspase 3D structures|Caspase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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[[Category: Caspase-3]]
[[Category: Caspase-3]]
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Miscellaneous nucleic acid]]
[[Category: Miscellaneous nucleic acid]]
[[Category: Barandun, J]]
[[Category: Barandun, J]]

Revision as of 14:57, 17 November 2021

Caspase-3 in Complex with an Inhibitory DARPin-3.4_S76R

PDB ID 2y0b

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