3qwm
From Proteopedia
(Difference between revisions)
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==Crystal Structure of GEP100, the plextrin homology domain of IQ motif and SEC7 domain-containing protein 1 isoform a== | ==Crystal Structure of GEP100, the plextrin homology domain of IQ motif and SEC7 domain-containing protein 1 isoform a== | ||
| - | <StructureSection load='3qwm' size='340' side='right' caption='[[3qwm]], [[Resolution|resolution]] 2.39Å' scene=''> | + | <StructureSection load='3qwm' size='340' side='right'caption='[[3qwm]], [[Resolution|resolution]] 2.39Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3qwm]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3qwm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QWM FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IQSEC1 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IQSEC1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qwm OCA], [https://pdbe.org/3qwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qwm RCSB], [https://www.ebi.ac.uk/pdbsum/3qwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qwm ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/IQEC1_HUMAN IQEC1_HUMAN]] In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin.<ref>PMID:11226253</ref> <ref>PMID:16461286</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Allerston, C]] | [[Category: Allerston, C]] | ||
[[Category: Arrowsmith, C H]] | [[Category: Arrowsmith, C H]] | ||
Revision as of 05:39, 15 June 2022
Crystal Structure of GEP100, the plextrin homology domain of IQ motif and SEC7 domain-containing protein 1 isoform a
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Categories: Human | Large Structures | Allerston, C | Arrowsmith, C H | Bountra, C | Chaikuad, A | Delft, F von | Edwards, A | Feller, S | Felletar, I | Filippakopoulos, P | Janning, M | Knapp, S | Krojer, T | Picaud, S | Structural genomic | Sabe, H | Weigelt, J | Alpha-catenin | Arf1 | Arf5 | Arf6 | Egfr | Guanine nucleotide exchange factor | Ph domain | Sgc | Signaling protein
