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3sa1
From Proteopedia
(Difference between revisions)
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==Bacuills anthracis Dihydrofolate Reductase bound propargyl-linked TMP analog, UCP1021== | ==Bacuills anthracis Dihydrofolate Reductase bound propargyl-linked TMP analog, UCP1021== | ||
| - | <StructureSection load='3sa1' size='340' side='right' caption='[[3sa1]], [[Resolution|resolution]] 2.50Å' scene=''> | + | <StructureSection load='3sa1' size='340' side='right'caption='[[3sa1]], [[Resolution|resolution]] 2.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3sa1]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3sa1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var. anthracis" (cohn 1872) smith et al. 1946]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SA1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SA1 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6DR:6-ETHYL-5-{3-[2-METHOXY-5-(PYRIDIN-4-YL)PHENYL]PROP-1-YN-1-YL}PYRIMIDINE-2,4-DIAMINE'>6DR</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6DR:6-ETHYL-5-{3-[2-METHOXY-5-(PYRIDIN-4-YL)PHENYL]PROP-1-YN-1-YL}PYRIMIDINE-2,4-DIAMINE'>6DR</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3sa2|3sa2]], [[3sai|3sai]], [[3e0b|3e0b]], [[3s9u|3s9u]], [[3jvx|3jvx]], [[3jwm|3jwm]], [[3jwc|3jwc]], [[3jwf|3jwf]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3sa2|3sa2]], [[3sai|3sai]], [[3e0b|3e0b]], [[3s9u|3s9u]], [[3jvx|3jvx]], [[3jwm|3jwm]], [[3jwc|3jwc]], [[3jwf|3jwf]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BAS2083, BA_2237, dfrA, GBAA2237, GBAA_2237 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BAS2083, BA_2237, dfrA, GBAA2237, GBAA_2237 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 "Bacillus cereus var. anthracis" (Cohn 1872) Smith et al. 1946])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sa1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sa1 OCA], [https://pdbe.org/3sa1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sa1 RCSB], [https://www.ebi.ac.uk/pdbsum/3sa1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sa1 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/Q81R22_BACAN Q81R22_BACAN]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194] |
==See Also== | ==See Also== | ||
| - | *[[Dihydrofolate reductase|Dihydrofolate reductase]] | + | *[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]] |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Dihydrofolate reductase]] | [[Category: Dihydrofolate reductase]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Anderson, A C]] | [[Category: Anderson, A C]] | ||
[[Category: Beierlein, J M]] | [[Category: Beierlein, J M]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
Revision as of 07:48, 29 June 2022
Bacuills anthracis Dihydrofolate Reductase bound propargyl-linked TMP analog, UCP1021
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