1msp

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1msp.gif|left|200px]]
[[Image:1msp.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1msp |SIZE=350|CAPTION= <scene name='initialview01'>1msp</scene>, resolution 2.5&Aring;
+
The line below this paragraph, containing "STRUCTURE_1msp", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= ALPHA MSP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6253 Ascaris suum])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1msp| PDB=1msp | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1msp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1msp OCA], [http://www.ebi.ac.uk/pdbsum/1msp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1msp RCSB]</span>
+
-
}}
+
'''MAJOR SPERM PROTEIN, ALPHA ISOFORM (RECOMBINANT), PH 4.6'''
'''MAJOR SPERM PROTEIN, ALPHA ISOFORM (RECOMBINANT), PH 4.6'''
Line 28: Line 25:
[[Category: Roberts, T M.]]
[[Category: Roberts, T M.]]
[[Category: Stewart, M.]]
[[Category: Stewart, M.]]
-
[[Category: cell motility protein]]
+
[[Category: Cell motility protein]]
-
[[Category: cytoskeletal protein]]
+
[[Category: Cytoskeletal protein]]
-
[[Category: sperm]]
+
[[Category: Sperm]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:40:43 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:20:39 2008''
+

Revision as of 22:40, 2 May 2008

Image:1msp.gif

Template:STRUCTURE 1msp

MAJOR SPERM PROTEIN, ALPHA ISOFORM (RECOMBINANT), PH 4.6


Overview

We have determined the structure of the Ascaris major sperm protein (MSP) to 2.5 A resolution using X-ray crystallography. The MSP polypeptide chain has an immunoglobulin-like fold based on a seven-stranded beta sandwich. In two strands, cis-proline residues impart distinctive kinks, and overall the structure most closely resembles that of the N-terminal domain of the bacterial chaperonin, PapD. In the C2 crystal form which we have solved here, two MSP chains are tightly associated in the asymmetric unit and are related by a non-crystallographic 2-fold rotation axis. This arrangement almost certainly represents the MSP dimer that is present in solution. Additionally, the arrangement of two MSP dimers at one of the crystallographic 2-fold axes in the 215 A unit cell suggests a possible mode for the assembly of MSP into the filaments which promote cell movement. This dimer-dimer association is based on a beta sheet extension mechanism between adjoining MSP monomers which resembles the interaction between PapD and its protein substrate.

About this Structure

1MSP is a Single protein structure of sequence from Ascaris suum. Full crystallographic information is available from OCA.

Reference

2.5 A resolution crystal structure of the motile major sperm protein (MSP) of Ascaris suum., Bullock TL, Roberts TM, Stewart M, J Mol Biol. 1996 Oct 25;263(2):284-96. PMID:8913307 Page seeded by OCA on Sat May 3 01:40:43 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1msp"
Personal tools