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1mtl

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[[Image:1mtl.jpg|left|200px]]
[[Image:1mtl.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1mtl |SIZE=350|CAPTION= <scene name='initialview01'>1mtl</scene>, resolution 2.80&Aring;
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The line below this paragraph, containing "STRUCTURE_1mtl", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=AAB:2-DEOXY-5-PHOSPHORIBOSE+GROUP'>AAB</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= MUG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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-->
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|DOMAIN=
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{{STRUCTURE_1mtl| PDB=1mtl | SCENE= }}
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|RELATEDENTRY=[[1mug|1MUG]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mtl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mtl OCA], [http://www.ebi.ac.uk/pdbsum/1mtl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mtl RCSB]</span>
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}}
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'''Non-productive MUG-DNA complex'''
'''Non-productive MUG-DNA complex'''
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[[Category: Pearl, L H.]]
[[Category: Pearl, L H.]]
[[Category: Savva, R.]]
[[Category: Savva, R.]]
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[[Category: cis-platin]]
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[[Category: Cis-platin]]
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[[Category: glycosylase]]
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[[Category: Glycosylase]]
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[[Category: inter-strand]]
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[[Category: Inter-strand]]
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[[Category: non-productive]]
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[[Category: Non-productive]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:42:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:20:58 2008''
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Revision as of 22:42, 2 May 2008

Image:1mtl.jpg

Template:STRUCTURE 1mtl

Non-productive MUG-DNA complex


Overview

Base-excision of a self-complementary oligonucleotide with central G:T mismatches by the G:T/U-specific mismatch DNA glycosylase (MUG), generates an unusual DNA structure which is remarkably similar in conformation to an interstrand DNA adduct of the anti-tumor drug cis-diamminedichloroplatinum. The abasic sugars generated by excision of the mismatched thymines are extruded from the double-helix, and the 'widowed' deoxyguanosines rotate so that their N7 and O6 groups protrude into the minor groove of the duplex and restack in an interleaved intercalative geometry, generating a kink in the helix axis.

About this Structure

1MTL is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of a DNA base-excision product resembling a cisplatin inter-strand adduct., Barrett TE, Savva R, Barlow T, Brown T, Jiricny J, Pearl LH, Nat Struct Biol. 1998 Aug;5(8):697-701. PMID:9699633 Page seeded by OCA on Sat May 3 01:42:02 2008

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