1mu2

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[[Image:1mu2.jpg|left|200px]]
[[Image:1mu2.jpg|left|200px]]
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{{Structure
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|PDB= 1mu2 |SIZE=350|CAPTION= <scene name='initialview01'>1mu2</scene>, resolution 2.35&Aring;
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The line below this paragraph, containing "STRUCTURE_1mu2", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= POL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11709 Human immunodeficiency virus 2])
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|DOMAIN=
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{{STRUCTURE_1mu2| PDB=1mu2 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mu2 OCA], [http://www.ebi.ac.uk/pdbsum/1mu2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mu2 RCSB]</span>
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'''CRYSTAL STRUCTURE OF HIV-2 REVERSE TRANSCRIPTASE'''
'''CRYSTAL STRUCTURE OF HIV-2 REVERSE TRANSCRIPTASE'''
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[[Category: Stewart-Jones, G B.]]
[[Category: Stewart-Jones, G B.]]
[[Category: Stuart, D I.]]
[[Category: Stuart, D I.]]
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[[Category: aid]]
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[[Category: Aid]]
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[[Category: drug design]]
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[[Category: Drug design]]
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[[Category: hiv-2 reverse transcriptase]]
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[[Category: Hiv-2 reverse transcriptase]]
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[[Category: polymerase]]
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[[Category: Polymerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:42:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:21:10 2008''
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Revision as of 22:42, 2 May 2008

Image:1mu2.jpg

Template:STRUCTURE 1mu2

CRYSTAL STRUCTURE OF HIV-2 REVERSE TRANSCRIPTASE


Overview

The HIV-2 serotype of HIV is a cause of disease in parts of the West African population, and there is evidence for its spread to Europe and Asia. HIV-2 reverse transcriptase (RT) demonstrates an intrinsic resistance to non-nucleoside RT inhibitors (NNRTIs), one of two classes of anti-AIDS drugs that target the viral RT. We report the crystal structure of HIV-2 RT to 2.35 A resolution, which reveals molecular details of the resistance to NNRTIs. HIV-2 RT has a similar overall fold to HIV-1 RT but has structural differences within the "NNRTI pocket" at both conserved and nonconserved residues. The structure points to the role of sequence differences that can give rise to unfavorable inhibitor contacts or destabilization of part of the binding pocket at positions 101, 106, 138, 181, 188, and 190. We also present evidence that the conformation of Ile-181 compared with the HIV-1 Tyr-181 could be a significant contributory factor to this inherent drug resistance of HIV-2 to NNRTIs. The availability of a refined structure of HIV-2 RT will provide a stimulus for the structure-based design of novel non-nucleoside inhibitors that could be used against HIV-2 infection.

About this Structure

1MU2 is a Protein complex structure of sequences from Human immunodeficiency virus 2. Full crystallographic information is available from OCA.

Reference

Structure of HIV-2 reverse transcriptase at 2.35-A resolution and the mechanism of resistance to non-nucleoside inhibitors., Ren J, Bird LE, Chamberlain PP, Stewart-Jones GB, Stuart DI, Stammers DK, Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14410-5. Epub 2002 Oct 17. PMID:12386343 Page seeded by OCA on Sat May 3 01:42:48 2008

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