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1mug

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[[Image:1mug.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1mug", creates the "Structure Box" on the page.
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{{STRUCTURE_1mug| PDB=1mug | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mug OCA], [http://www.ebi.ac.uk/pdbsum/1mug PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mug RCSB]</span>
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'''G:T/U MISMATCH-SPECIFIC DNA GLYCOSYLASE FROM E.COLI'''
'''G:T/U MISMATCH-SPECIFIC DNA GLYCOSYLASE FROM E.COLI'''
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[[Category: Pearl, L H.]]
[[Category: Pearl, L H.]]
[[Category: Savva, R.]]
[[Category: Savva, R.]]
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[[Category: dna-glycosylase]]
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[[Category: Dna-glycosylase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:43:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:21:14 2008''
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Revision as of 22:43, 2 May 2008

Image:1mug.gif

Template:STRUCTURE 1mug

G:T/U MISMATCH-SPECIFIC DNA GLYCOSYLASE FROM E.COLI


Overview

G:U mismatches resulting from deamination of cytosine are the most common promutagenic lesions occurring in DNA. Uracil is removed in a base-excision repair pathway by uracil DNA-glycosylase (UDG), which excises uracil from both single- and double-stranded DNA. Recently, a biochemically distinct family of DNA repair enzymes has been identified, which excises both uracil and thymine, but only from mispairs with guanine. Crystal structures of the mismatch-specific uracil DNA-glycosylase (MUG) from E. coli, and of a DNA complex, reveal a remarkable structural and functional homology to UDGs despite low sequence identity. Details of the MUG structure explain its thymine DNA-glycosylase activity and the specificity for G:U/T mispairs, which derives from direct recognition of guanine on the complementary strand.

About this Structure

1MUG is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions., Barrett TE, Savva R, Panayotou G, Barlow T, Brown T, Jiricny J, Pearl LH, Cell. 1998 Jan 9;92(1):117-29. PMID:9489705 Page seeded by OCA on Sat May 3 01:43:46 2008

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