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1muj
From Proteopedia
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'''Crystal structure of murine class II MHC I-Ab in complex with a human CLIP peptide''' | '''Crystal structure of murine class II MHC I-Ab in complex with a human CLIP peptide''' | ||
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[[Category: Wilson, I A.]] | [[Category: Wilson, I A.]] | ||
[[Category: Zhu, Y.]] | [[Category: Zhu, Y.]] | ||
| - | [[Category: | + | [[Category: Antigen]] |
| - | [[Category: | + | [[Category: Clip]] |
| - | [[Category: | + | [[Category: Complex]] |
| - | [[Category: | + | [[Category: Crystal structure]] |
| - | [[Category: | + | [[Category: I-ab]] |
| - | [[Category: | + | [[Category: Peptide]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:44:17 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 22:44, 2 May 2008
Crystal structure of murine class II MHC I-Ab in complex with a human CLIP peptide
Overview
Association between the class II major histocompatibility complex (MHC) and the class II invariant chain-associated peptide (CLIP) occurs naturally as an intermediate step in the MHC class II processing pathway. Here, we report the crystal structure of the murine class II MHC molecule I-A(b) in complex with human CLIP at 2.15A resolution. The structure of I-A(b) accounts, via the peptide-binding groove's unique physicochemistry, for the distinct peptide repertoire bound by this allele. CLIP adopts a similar conformation to peptides bound by other I-A alleles, reinforcing the notion that CLIP is presented as a conventional peptide antigen. When compared to the related HLA-DR3/CLIP complex structure, the CLIP peptide displays a slightly different conformation and distinct interaction pattern with residues in I-A(b). In addition, after examining the published sequences of peptides presented by I-A(b), we discuss the possibility of predicting peptide alignment in the I-A(b) binding groove using a simple scoring matrix.
About this Structure
1MUJ is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif., Zhu Y, Rudensky AY, Corper AL, Teyton L, Wilson IA, J Mol Biol. 2003 Feb 28;326(4):1157-74. PMID:12589760 Page seeded by OCA on Sat May 3 01:44:17 2008
Categories: Homo sapiens | Mus musculus | Protein complex | Wilson, I A. | Zhu, Y. | Antigen | Clip | Complex | Crystal structure | I-ab | Peptide
