1muj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1muj.gif|left|200px]]
[[Image:1muj.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1muj |SIZE=350|CAPTION= <scene name='initialview01'>1muj</scene>, resolution 2.15&Aring;
+
The line below this paragraph, containing "STRUCTURE_1muj", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1muj| PDB=1muj | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1muj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1muj OCA], [http://www.ebi.ac.uk/pdbsum/1muj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1muj RCSB]</span>
+
-
}}
+
'''Crystal structure of murine class II MHC I-Ab in complex with a human CLIP peptide'''
'''Crystal structure of murine class II MHC I-Ab in complex with a human CLIP peptide'''
Line 28: Line 25:
[[Category: Wilson, I A.]]
[[Category: Wilson, I A.]]
[[Category: Zhu, Y.]]
[[Category: Zhu, Y.]]
-
[[Category: antigen]]
+
[[Category: Antigen]]
-
[[Category: clip]]
+
[[Category: Clip]]
-
[[Category: complex]]
+
[[Category: Complex]]
-
[[Category: crystal structure]]
+
[[Category: Crystal structure]]
-
[[Category: i-ab]]
+
[[Category: I-ab]]
-
[[Category: peptide]]
+
[[Category: Peptide]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:44:17 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:21:17 2008''
+

Revision as of 22:44, 2 May 2008

Image:1muj.gif

Template:STRUCTURE 1muj

Crystal structure of murine class II MHC I-Ab in complex with a human CLIP peptide


Overview

Association between the class II major histocompatibility complex (MHC) and the class II invariant chain-associated peptide (CLIP) occurs naturally as an intermediate step in the MHC class II processing pathway. Here, we report the crystal structure of the murine class II MHC molecule I-A(b) in complex with human CLIP at 2.15A resolution. The structure of I-A(b) accounts, via the peptide-binding groove's unique physicochemistry, for the distinct peptide repertoire bound by this allele. CLIP adopts a similar conformation to peptides bound by other I-A alleles, reinforcing the notion that CLIP is presented as a conventional peptide antigen. When compared to the related HLA-DR3/CLIP complex structure, the CLIP peptide displays a slightly different conformation and distinct interaction pattern with residues in I-A(b). In addition, after examining the published sequences of peptides presented by I-A(b), we discuss the possibility of predicting peptide alignment in the I-A(b) binding groove using a simple scoring matrix.

About this Structure

1MUJ is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif., Zhu Y, Rudensky AY, Corper AL, Teyton L, Wilson IA, J Mol Biol. 2003 Feb 28;326(4):1157-74. PMID:12589760 Page seeded by OCA on Sat May 3 01:44:17 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1muj"
Personal tools