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| | ==Crystal Structure of Human SMN YG-Dimer== | | ==Crystal Structure of Human SMN YG-Dimer== |
| - | <StructureSection load='4gli' size='340' side='right' caption='[[4gli]], [[Resolution|resolution]] 1.90Å' scene=''> | + | <StructureSection load='4gli' size='340' side='right'caption='[[4gli]], [[Resolution|resolution]] 1.90Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4gli]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GLI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GLI FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4gli]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GLI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GLI FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">malE, b4034, JW3994, SMN, SMN1, SMN2, SMNC, SMNT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gli OCA], [https://pdbe.org/4gli PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gli RCSB], [https://www.ebi.ac.uk/pdbsum/4gli PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gli ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gli OCA], [http://pdbe.org/4gli PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gli RCSB], [http://www.ebi.ac.uk/pdbsum/4gli PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gli ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides. | + | [https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/SMN_HUMAN SMN_HUMAN] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Human]] | + | [[Category: Escherichia coli]] |
| - | [[Category: Duyne, G D.Van]] | + | [[Category: Homo sapiens]] |
| - | [[Category: Martin, R S]] | + | [[Category: Large Structures]] |
| - | [[Category: Perry, K]] | + | [[Category: Martin RS]] |
| - | [[Category: Soluble glycine zipper]] | + | [[Category: Perry K]] |
| - | [[Category: Splicing]] | + | [[Category: Van Duyne GD]] |
| - | [[Category: Sugar binding protein]]
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| Structural highlights
Function
MALE_ECOLI Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.SMN_HUMAN
Publication Abstract from PubMed
The survival motor neuron (SMN) protein forms the oligomeric core of a multiprotein complex that functions in spliceosomal snRNP biogenesis. Loss of function mutations in the SMN gene cause spinal muscular atrophy (SMA), a leading genetic cause of infant mortality. Nearly half of the known SMA patient missense mutations map to the SMN YG-box, a highly conserved oligomerization domain of unknown structure that contains a (YxxG)(3) motif. Here, we report that the SMN YG-box forms helical oligomers similar to the glycine zippers found in transmembrane channel proteins. A network of tyrosine-glycine packing between helices drives formation of soluble YG-box oligomers, providing a structural basis for understanding SMN oligomerization and for relating defects in oligomerization to the mutations found in SMA patients. These results have important implications for advancing our understanding of SMN function and glycine zipper-mediated helix-helix interactions.
The Survival Motor Neuron Protein Forms Soluble Glycine Zipper Oligomers.,Martin R, Gupta K, Ninan NS, Perry K, Van Duyne GD Structure. 2012 Sep 25. pii: S0969-2126(12)00327-9. doi:, 10.1016/j.str.2012.08.024. PMID:23022347[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Martin R, Gupta K, Ninan NS, Perry K, Van Duyne GD. The Survival Motor Neuron Protein Forms Soluble Glycine Zipper Oligomers. Structure. 2012 Sep 25. pii: S0969-2126(12)00327-9. doi:, 10.1016/j.str.2012.08.024. PMID:23022347 doi:http://dx.doi.org/10.1016/j.str.2012.08.024
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